ArticleScientific reports2023
Enhanced production of a recombinant xylanase (XT6): optimization of production and purification, and scaled-up batch fermentation in a stirred tank bioreactor.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- A hybrid statistical-machine learning framework for optimization, prediction, and model-fitting of xylose and total sugar production from sugarcane bagasse using recombinant Escherichia coli-mediated hydrolysis.Archives of microbiology · 2026Article
- Endo-β-1,4-Xylanase GH10 fromInternational journal of molecular sciences · 2026Article
- A thermostable GH10 xylanase from Anoxybacteroides tepidamans: structural insights and biochemical characterization.Molecular biology reports · 2026Article
- Study of Fermentation Conditions Optimization for Xylanase Production byFoods (Basel, Switzerland) · 2026Article
- Isolation, expression, and in silico profiling of a thermostable xylanase from Geobacillus stearothermophilus strain NASA267: insights into structural features and agro-waste valorization.Microbial cell factories · 2025Article
- Optimization of Xylooligosaccharides Production by Native and Recombinant Xylanase Hydrolysis of Chicken Feed Substrates.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The endoxylanase XT6 produced by Geobacillus stearothermophilus is a desirable candidate for industrial applications. In this study, the gene encoding XT6 was cloned using the pET-28a expression vector and expressed in Escherichia coli BL21 (DE3) cells. Recombinant XT6 production was improved by optimizing cell lysis (sonication, chemical, and enzymatic lysis) and expression conditions. Sonication in a 0.05 M sodium phosphate (pH 6.0) buffer resulted in the highest xylanase activity (16.48 U/ml). Screening and optimization of induction conditions using the Plackett-Burman Design and Box-Behnken Design (BBD) approaches revealed that cell density pre-induction (OD
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Registered trials
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