Evidence map›Paper›PMID 38016782›Full record

ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2023

[Research progress on the mechanism and response strategies of molecular targeted drug resistance in liver cancer].

M F Song, L Y Ma, Q Zhao, C Shen, C Y Zhao

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M F SongDepartment of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
L Y MaDepartment of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Q ZhaoQuality Management and Control Office, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
C ShenDepartment of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
C Y ZhaoDepartment of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Funding

Hebei Provincial Medical Talents Project 81900536Innovation Ability Promotion Project of Hebei Infectious Disease Clinical Medical Research Center S&T Program of Hebei, 20577704DNational Natural Science Foundation of China Youth Science Foundation
6 · The paper itself

Abstract

Molecular targeted drugs are one of the treatments for hepatocellular carcinoma (HCC), the primary factor influencing their therapeutic efficacy is drug resistance. Diminished drug intake, greater efflux, improved DNA damage repair capacity, aberrant signal pathways, hypoxia, epithelial-mesenchymal cell transition, and the cellular autophagy system are summarized herein as aspects of the drug resistance mechanism. Simultaneously, effective strategies for addressing drug resistance are elaborated, providing ideas for better clinical treatment of HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsCell Line, TumorDrug ResistanceDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionHumansMolecular Targeted TherapySignal TransductionCoping strategiesDrug resistance mechanismHepatocellular carcinoma

Identifiers

PMID38016782
PMCPMC12813785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.