Evidence map›Paper›PMID 38016751›Full record

ArticleSaudi medical journal2023

A descriptive analysis of gastric cancer with an immunohistochemical Study of Ki67 and p53 as prognostic factors.: Bahrain experience.

Mohmmed Awadh, Aysha Darwish, Huda Alqatari, Fatema M Buzaid, Abdulla Darwish

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mohmmed AwadhFrom the Department of Pathology (Awadh), from the Department of Pathology (Darwish), and from the Department of Training (Buzaid), Crown Prince Centre for Training and Medical Research, Bahrain Defense Force Royal Medical Services; from the Department of Surgery (Darwish, Alqatari), Royal College of Surgeons in Ireland - Medical University of Bahrain, Albussatun, Bahrain.ORCID https://orcid.org/0000-0003-0381-3026
Aysha DarwishFrom the Department of Pathology (Awadh), from the Department of Pathology (Darwish), and from the Department of Training (Buzaid), Crown Prince Centre for Training and Medical Research, Bahrain Defense Force Royal Medical Services; from the Department of Surgery (Darwish, Alqatari), Royal College of Surgeons in Ireland - Medical University of Bahrain, Albussatun, Bahrain.
Huda AlqatariFrom the Department of Pathology (Awadh), from the Department of Pathology (Darwish), and from the Department of Training (Buzaid), Crown Prince Centre for Training and Medical Research, Bahrain Defense Force Royal Medical Services; from the Department of Surgery (Darwish, Alqatari), Royal College of Surgeons in Ireland - Medical University of Bahrain, Albussatun, Bahrain.
Fatema M BuzaidFrom the Department of Pathology (Awadh), from the Department of Pathology (Darwish), and from the Department of Training (Buzaid), Crown Prince Centre for Training and Medical Research, Bahrain Defense Force Royal Medical Services; from the Department of Surgery (Darwish, Alqatari), Royal College of Surgeons in Ireland - Medical University of Bahrain, Albussatun, Bahrain.
Abdulla DarwishFrom the Department of Pathology (Awadh), from the Department of Pathology (Darwish), and from the Department of Training (Buzaid), Crown Prince Centre for Training and Medical Research, Bahrain Defense Force Royal Medical Services; from the Department of Surgery (Darwish, Alqatari), Royal College of Surgeons in Ireland - Medical University of Bahrain, Albussatun, Bahrain.
Royal College of Surgeons in Ireland - Bahrain · BH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe the increasing number of gastric cancer cases at Bahrain Defense Force Hospital with implementation of immunohistochemistry markers as prognostic factors.

methodsThis study included histologically confirmed malignant gastric tumors diagnosed at Bahrain Defense Force Hospital from January 2009 to June 2019. Various epidemiological and pathological data were abstracted and recorded with immunohistochemical analysis of the proliferation marker Ki67 and cell-cycle regulator p53 as prognostic factors.

resultsA total of 53 patients with gastric cancer were included in the study, with mean age of 59.75 ± 12.9 years. The typical histological types were signet ring cell adenocarcinoma (68%) and intestinal type adenocarcinoma (17%). Helicobacter pylori and intestinal metaplasia were significantly associated with gastric cancer (

conclusionThe common gastric cancers are signet ring cell adenocarcinoma and intestinal type adenocarcinoma, affecting a wide range of age groups (33-91 years), with those over 60 years at greater risk. Interestingly, low Ki67 is associated with a higher mortality rate, whereas p53 has no prognostic significance. Expression of both Ki67 and p53 showed no association with survival time.

Indexed as

AdenocarcinomaCarcinoma, Signet Ring CellStomach NeoplasmsAdultAgedAged, 80 and overBahrainHumansKi-67 AntigenMiddle AgedPrognosisTumor Suppressor Protein p53Ki-67 AntigenTumor Suppressor Protein p53Bahrainepidemiologygastric cancerhistopathologyKi67p53

Identifiers

PMID38016751
PMCPMC10712787
OpenAlexW4389099591

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.