Evidence map›Paper›PMID 38016496›Full record

ArticleEnvironmental research2024

Prenatal and childhood exposure to organophosphate pesticides and functional brain imaging in young adults.

Sharon K Sagiv, Joseph M Baker, Stephen Rauch, Yuanyuan Gao, Robert B Gunier, Ana M Mora, Katherine Kogut, Asa Bradman, Brenda Eskenazi, Allan L Reiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sharon K SagivCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA. Electronic address: sagiv@berkeley.edu.
Joseph M BakerCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, USA.
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Yuanyuan GaoCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, USA.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Ana M MoraCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Katherine KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA.
Asa BradmanCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA; Department of Public Health, University of California, Merced, CA, USA.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, CA, USA. Electronic address: eskenazi@berkeley.edu.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA; Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: areiss1@stanford.edu.
Berkeley Public Health Division · USStanford University · USStanford Medicine · USUniversity of California, Merced · US

Funding

TRAINING FOR CHILD PSYCHIATRY AND CHILD DEVELOPMENTT32MH019908 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB, DAVID S HONG · 1993 to 2026
$6.3M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Early life exposure to agricultural pesticides and functional brain imaging in young adultsR21ES032592 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI REISS, ALLAN L, SAGIV, SHARON K. · 2021 to 2022
$453k
NIEHS NIH HHS R21 ES032592NIEHS NIH HHS U24 ES028529NIMH NIH HHS T32 MH019908
6 · The paper itself

Abstract

backgroundEarly life exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment from infancy to adolescence. In our Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) birth cohort, we previously reported that residential proximity to OP use during pregnancy was associated with altered cortical activation using functional near infrared spectroscopy (fNIRS) in a small subset (n = 95) of participants at age 16 years.

methodsWe administered fNIRS to 291 CHAMACOS young adults at the 18-year visit. Using covariate-adjusted regression models, we estimated associations of prenatal and childhood urinary dialkylphosphates (DAPs), non-specific OP metabolites, with cortical activation in the frontal, temporal, and parietal regions of the brain during tasks of executive function and semantic language.

resultsThere were some suggestive associations for prenatal DAPs with altered activation patterns in both the inferior frontal and inferior parietal lobes of the left hemisphere during a task of cognitive flexibility (β per ten-fold increase in DAPs = 3.37; 95% CI: -0.02, 6.77 and β = 3.43; 95% CI: 0.64, 6.22, respectively) and the inferior and superior frontal pole/dorsolateral prefrontal cortex of the right hemisphere during the letter retrieval working memory task (β = -3.10; 95% CI: -6.43, 0.22 and β = -3.67; 95% CI: -7.94, 0.59, respectively). We did not observe alterations in cortical activation with prenatal DAPs during a semantic language task or with childhood DAPs during any task. DISCUSSION: We observed associations of prenatal OP concentrations with mild alterations in cortical activation during tasks of executive function. Associations with childhood exposure were null. This is reasonably consistent with studies of prenatal OPs and neuropsychological measures of attention and executive function found in CHAMACOS and other birth cohorts.

Indexed as

InsecticidesPesticidesPrenatal Exposure Delayed EffectsAdolescentBrainChildFemaleFunctional NeuroimagingHumansMaternal ExposureOrganophosphatesOrganophosphorus CompoundsPregnancyInsecticidesOrganophosphatesOrganophosphorus CompoundsPesticidesDialkyl phosphatesfNIRSNeurodevelopmentNeuroimagingOrganophosphatesPrenatal

Identifiers

PMID38016496
PMCPMC11298288
OpenAlexW4389009960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.