Evidence map›Paper›PMID 38016492›Full record

ArticleBrain, behavior, and immunity2024

Regulatory T-cell phenotypes in prenatal psychological distress.

Kyle S Wiley, Dayoon Kwon, Delaney A Knorr, Molly M Fox

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. CD4Neurobiology of stress · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kyle S WileyDepartment of Anthropology, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States. Electronic address: kyleswiley@ucla.edu.
Dayoon KwonDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, United States.
Delaney A KnorrDepartment of Anthropology, University of California, Los Angeles, United States.
Molly M FoxDepartment of Anthropology, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States.
University of California, Los Angeles · US

Funding

Effects of Acculturation on Gestational Biology in Mexican-American Pregnant WomenK01DK105110 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2015 to 2021
$782k
Social adversity, gestational stress physiology, and birth outcomes in Hispanic AmericansR03DK125524 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOX, MOLLY MAURER · 2020 to 2021
$234k
Mental health across generations of Hispanic Americans: investigating the biomechanism of fetal programmingF32MD015201 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILEY, KYLE STEVEN · 2020 to 2022
$198k
NIDDK NIH HHS K01 DK105110NIDDK NIH HHS R03 DK125524NIMHD NIH HHS F32 MD015201
6 · The paper itself

Abstract

backgroundExperiencing symptoms of psychological distress during pregnancy is common and has been linked to dysregulated immune functioning. In this context, immunoregulatory function is especially relevant because of its crucial role in establishment and maintenance of healthy pregnancy. However, little research has examined associations between women's prenatal psychological distress and immunoregulatory biomarkers. We investigated how symptoms of depression, anxiety, and stress relate to circulating levels of regulatory T-cells (Tregs). MATERIALS AND

methodsPregnant Latina women were assessed at around 12 weeks of pregnancy (N = 82). These assessments included blood draws and self-report questionnaires assessing symptoms of depression, state anxiety, pregnancy-related anxiety, and perceived stress. Flow cytometry on PBMCs was used to quantify circulating Tregs, defined as CD3

resultsState anxiety symptoms at 12 weeks were negatively associated with parent Treg cell levels (b = -4.02, p = 0.023) and subpopulations Helios

conclusionOur observation that symptoms of anxiety and stress are related to tolerogenic immunology suggests a possible biomechanism explaining correlations of maternal mood disorders with adverse outcomes for mothers and offspring.

Indexed as

Programmed Cell Death 1 ReceptorT-Lymphocytes, RegulatoryBiomarkersFemaleFlow CytometryForkhead Transcription FactorsHumansPhenotypePregnancyStress, PsychologicalBiomarkersForkhead Transcription FactorsProgrammed Cell Death 1 ReceptorAnxietyDepressionPregnancyPrenatal moodRegulatory T-cellsStress

Identifiers

PMID38016492
PMCPMC11402516
OpenAlexW4389009161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.