ArticleNeuron2024
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.
Open access · greenAbstract read
In one paragraph
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Bibliometric and visual analysis of single-cell multiomics in neurodegenerative disease arrest studies.Frontiers in neurology · 2024Pooled it
- Review
- Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1.The Journal of clinical investigation · 2026Article
- Single-Cell RNA Sequencing Reveals Impaired CHIP-Mediated Heat Stress Response in SCA3 Pathogenesis.Molecular neurobiology · 2026Article
- Longitudinal omics data analysis: approaches and applications.Computational and structural biotechnology journal · 2026Review
- MSK1 Downstream Signaling Contributes to Inflammatory Pain in the Superficial Spinal Dorsal Horn.International journal of molecular sciences · 2025Article
- Translational Relevance of SCA1 Models for the Development of Therapies for Spinocerebellar Ataxia Type 1.Biomedicines · 2025Review
- TMEM206 gene knockout improves balance performance in SCA1 transgenic mice.IBRO neuroscience reports · 2025Article
- Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Disrupted Transcriptional Networks in Mammalian Cells Stably Over-Expressing Pathogenic Atrophin-1.Journal of neuroscience research · 2025Article
- Fixel-Based Analysis of Diffusion Imaging as a Quantitative Marker of Disease State in Spinocerebellar Ataxia.Annals of clinical and translational neurology · 2025Article
- Disrupted Transcriptional Networks by Mutant Atrophin-1 in a Cell Culture Model of Dentatorubral-Pallidoluysian Atrophy.bioRxiv : the preprint server for biology · 2025Article
- Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics.Neuron · 2025Article
- Essential new insights into human cerebellar Purkinje cell biology from studies of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanism of cytarabine-induced neurotoxicity.Nature · 2025Article
- Review
- Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.Molecular neurodegeneration · 2025Article
- Spatial Omics in Clinical Research: A Comprehensive Review of Technologies and Guidelines for Applications.International journal of molecular sciences · 2025Review
- Sex Differences in a Novel Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1).International journal of molecular sciences · 2025Article
- Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.Science translational medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 9 institutions in 1 country.
Leon TejwaniInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: leon.tejwani@yale.edu.
Neal G RavindraCardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Computer Science, Yale University, New Haven, CT 06510, USA.
Changwoo LeeInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Yubao ChengDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Billy NguyenUniversity of California, San Francisco School of Medicine, San Francisco, CA 94143, USA.
Kimberly LuttikInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Luhan NiDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Shupei ZhangDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Logan M MorrisonDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
John GioncoDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA.
Yangfei XiangDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA.
Jennifer YoonYale College, New Haven, CT 06510, USA.
Hannah RoYale College, New Haven, CT 06510, USA.
Fatema HaideryYale College, New Haven, CT 06510, USA.
Rosalie M GrijalvaInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Eunwoo BaeYale College, New Haven, CT 06510, USA.
Kristen KimInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA.
Regina T MartuscelloDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA.
Harry T OrrDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Huda Y ZoghbiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Hayley S McLoughlinDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA.
Laura P W RanumDepartment of Molecular Genetics and Microbiology, Center for Neurogenetics, College of Medicine, Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Vikram G ShakkottaiDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Phyllis L FaustDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center and the New York Presbyterian Hospital, New York, NY 10032, USA.
Siyuan WangDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: siyuan.wang@yale.edu.
David van DijkCardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Computer Science, Yale University, New Haven, CT 06510, USA. Electronic address: david.vandijk@yale.edu.
Janghoo LimInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT 06510, USA; Wu Tsai Institute, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: janghoo.lim@yale.edu.
Yale University · USNewYork–Presbyterian Hospital · USUniversity of Michigan · USYale Cancer Center · USTexas Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Francisco · USUniversity of Florida · USUniversity of Minnesota · US
Funding
Interdepartmental Neuroscience Program (INP)T32NS041228 · NINDS · YALE UNIVERSITY · PI Charles A Greer, Marina R Picciotto · 2001 to 2026
$12.0MMichigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1MMOLECULAR STUDIES OF SPINOCEREBELLAR ATAXIA TYPE 1R01NS027699 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI HUDA Y ZOGHBI · 1989 to 2026
$8.8MNEUROBIOLOGY OF CORTICAL SYSTEMST32NS007224 · NINDS · YALE UNIVERSITY · PI CARDIN, JESSICA A · 1985 to 2025
$4.6MIdentifying symptomatic and neuroprotective strategies for cerebellar ataxiaR01NS085054 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI SHAKKOTTAI, VIKRAM GOVINDARAJU · 2013 to 2023
$4.3MEvaluation of a novel NLK function in lysosome biogenesis and neurodegenerative diseasesR01AG074609 · NIA · YALE UNIVERSITY · PI LIM, JANGHOO · 2021 to 2025
$4.0MInvestigation of the role of ATXN1 in oligodendroglia and neurodegenerative diseasesR01AG076154 · NIA · YALE UNIVERSITY · PI Janghoo Lim · 2022 to 2026
$3.5MEarly Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1MMicroglial regulation of Progranulin levelsR01AG066447 · NIA · YALE UNIVERSITY · PI LIM, JANGHOO · 2020 to 2024
$3.1MCellular and Molecular Studies of SBMA Neuromuscular DiseaseR01NS088321 · NINDS · YALE UNIVERSITY · PI LIM, JANGHOO · 2015 to 2019
$2.2MIntegrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissueR01HG011245 · NHGRI · YALE UNIVERSITY · PI WANG, SIYUAN · 2020 to 2023
$2.1MInvestigating the Pathogenesis of Cerebellar NeurodegenerationR01NS083706 · NINDS · YALE UNIVERSITY · PI LIM, JANGHOO · 2014 to 2018
$1.8MNHGRI NIH HHS R01 HG011245NIA NIH HHS P30 AG053760NIA NIH HHS R01 AG066447NIA NIH HHS R01 AG074609NIA NIH HHS R01 AG076154NIMH NIH HHS R21 MH119803NINDS NIH HHS R01 NS027699NINDS NIH HHS R01 NS083706NINDS NIH HHS R01 NS085054NINDS NIH HHS R01 NS088321NINDS NIH HHS T32 NS007224NINDS NIH HHS T32 NS041228NINDS NIH HHS T32 NS076401
Abstract
Neurodegeneration is a protracted process involving progressive changes in myriad cell types that ultimately results in the death of vulnerable neuronal populations. To dissect how individual cell types within a heterogeneous tissue contribute to the pathogenesis and progression of a neurodegenerative disorder, we performed longitudinal single-nucleus RNA sequencing of mouse and human spinocerebellar ataxia type 1 (SCA1) cerebellar tissue, establishing continuous dynamic trajectories of each cell population. Importantly, we defined the precise transcriptional changes that precede loss of Purkinje cells and, for the first time, identified robust early transcriptional dysregulation in unipolar brush cells and oligodendroglia. Finally, we applied a deep learning method to predict disease state accurately and identified specific features that enable accurate distinction of wild-type and SCA1 cells. Together, this work reveals new roles for diverse cerebellar cell types in SCA1 and provides a generalizable analysis framework for studying neurodegeneration.
Indexed as
Spinocerebellar AtaxiasAnimalsAtaxin-1CerebellumDisease Models, AnimalHumansMiceMice, TransgenicPurkinje CellsAtaxin-1ataxin-1machine learningneurodegenerationoligodendrocyteoligodendrocyte progenitor cellPurkinje cellSCA1single-nucleus RNA sequencingspinocerebellar ataxia type 1unipolar brush cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.