ArticleCell2023
TScan-II: A genome-scale platform for the de novo identification of CD4
Open access · hybridAbstract readComment
In one paragraph
Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- Entering the Age of Specificity in T Cell Immunity.Immunological reviews · 2026Review
- Discovery of Post-Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat.Immunological reviews · 2026Review
- A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.Cell · 2026Article
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Distinguishing Ile/Leu Variant Ligands in the Immunopeptidome Using Hybrid EAD + CID Fragmentation (ExCID).Analytical chemistry · 2026Article
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- Identification of a shared antigen linking CD4Science advances · 2026Article
- Article
- T Cell Antigen Discovery Using Cell-Based Epitope Libraries.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Identification of Sjögren's disease-associated T cell receptor motifs through deep sequencing.JCI insight · 2025Article
- Targeting the roots of myeloid malignancies with T cell receptors.Nature reviews. Cancer · 2025Review
- Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses.The Journal of experimental medicine · 2025Article
- T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database.Cell systems · 2025Article
- Identifying T cell antigen at the atomic level with graph convolutional network.Nature communications · 2025Article
- Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.Science advances · 2025Article
- Protein Engineering for Spatiotemporally Resolved Cellular Monitoring.Annual review of analytical chemistry (Palo Alto, Calif.) · 2025Review
- Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome.Chemical reviews · 2025Review
- High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.Nature biotechnology · 2025Article
- Comprehensive epitope mutational scan database enables accurate T cell receptor cross-reactivity prediction.bioRxiv : the preprint server for biology · 2025Article
- Developing T Cell Epitope-Based Vaccines Against Infection: Challenging but Worthwhile.Vaccines · 2025Review
Corrections and comments
- Comment on
Authors and funding
19 authors at 5 institutions in 1 country.
Mohammad H DezfulianDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Tomasz KulaDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Thomas PranzatelliAdeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Nolan KamitakiDepartment of Genetics, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Qingda MengDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Bhuwan KhatriGenes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Paola PerezSalivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Qikai XuDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Aiquan ChangDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ayano C KohlgruberDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Yumei LengDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Ananth Aditya JupudiArthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Departmentment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Michelle L JoachimsGenes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
John A ChioriniAdeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Christopher J LessardGenes and Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
A Darise FarrisArthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Departmentment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Senthil K MuthuswamyLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Blake M WarnerSalivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Stephen J ElledgeDivision of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA. Electronic address: selledge@genetics.med.harvard.edu.
Brigham and Women's Hospital · USNational Institutes of Health · USOklahoma Medical Research Foundation · USBroad Institute · USHarvard University · US
Funding
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MDiscovery and Characterization of Genetic Risk Loci in Sjogren's SyndromeR01AR073855 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI LESSARD, CHRISTOPHER J · 2020 to 2024
$3.7MClinical Investigations Of Sjogren's SyndromeZ01DE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ILLEI, GABOR · 2002 to 2008
$3.0MSpecificity and Molecular Definition of Pathogenic Lymphocytes in Sjogren's SyndromeR01AR074310 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI FARRIS, A DARISE · 2018 to 2022
$2.7MDevelopment of Highly Multiplex Antigen Specificity AssaysU24AI118633 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ELLEDGE, STEPHEN J, LARMAN, HARRY BENJAMIN · 2015 to 2020
$2.4MAnalysis of the Mammalian DNA Damage ResponseR01CA234600 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELLEDGE, STEPHEN J · 2019 to 2023
$2.0MIntramural NIH HHS Z01 DE000704NCI NIH HHS R01 CA234600NHGRI NIH HHS T32 HG002295NIAID NIH HHS U24 AI118633NIAMS NIH HHS R01 AR073855NIAMS NIH HHS R01 AR074310
Abstract
CD4
Indexed as
CD4-Positive T-LymphocytesEpitopes, T-LymphocyteAntigen-Presenting CellsCD4 AntigensCell LineGenome, HumanHLA AntigensHumansReceptors, Antigen, T-CellCD4 AntigensEpitopes, T-LymphocyteHLA AntigensReceptors, Antigen, T-Cellantigen discoveryantigen libraryCD4+ T cellepitope discoveryepitope mutagenesisHIVPancreatic cancerSjögren’s diseaseT cell epitopeT cell screening
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.