ArticleThe Plant cell2024
A major role of coumarin-dependent ferric iron reduction in strategy I-type iron acquisition in Arabidopsis.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Cross-Species Plasticity and Divergence Under Alkaline Soil Signature Conditions Differentiating PYE From FIT Target Transcripts in the Arabidopsis thaliana Ferrome.Plant, cell & environment · 2026Article
- Harnessing plant-exuded prebiotics as a next-generation strategy for sustainable agriculture.Journal of integrative plant biology · 2026Review
- Review
- TOP1α-mediated stabilization of CYP82C4 G-quadruplex DNA represses lateral root primordium initiation in Arabidopsis.Nature plants · 2026Article
- The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition.The New phytologist · 2026Article
- Rhizobacteria opportunistically boost colonization and impair plant fitness by degrading plant-derived coumarins under iron deficiency.Nature communications · 2026Article
- Plant Growth-Promoting Microorganisms Mediate Plant Metabolic Reprogramming to Manage the Rhizospheric Microbiome.Microorganisms · 2026Review
- The Volatile Pentadecane From Bacillus Alleviates Plant Iron Deficiency Through Activating the Reduction-Based Fe Uptake System.Plant biotechnology journal · 2026Article
- Arbuscular mycorrhizal fungi regulate mineral element distribution in grapevines under pH stress.Frontiers in plant science · 2026Article
- Correlation analysis of secondary metabolites, metal elements, and anti-BSA denaturation activity in different parts ofFrontiers in plant science · 2026Article
- Genetically Reprogramming Crops and Rhizobacteria for Nutritional Iron Biofortification.ACS synthetic biology · 2025Review
- Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates Arabidopsis iron nutrition.The New phytologist · 2025Article
- Microbial drivers of root plasticity.The New phytologist · 2025Review
- Guns in rosettes: The Arabidopsis chemical weapons arsenal.Plant physiology · 2025Review
- Coumarin-facilitated iron transport: An IRT1-independent strategy for iron acquisition in Arabidopsis thaliana.Plant communications · 2025Article
- Pumping iron, keeping FIT: How MYB30 regulates FIT stability during plant iron deficiency.The Plant cell · 2025Article
- The Genome of the Lima Bean Variety Baiyu Bean Highlights Its Evolutionary Characteristics.Ecology and evolution · 2025Article
- Combating plant diseases through transition metal allocation.The New phytologist · 2025Review
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Many non-graminaceous species release various coumarins in response to iron (Fe) deficiency. However, the physiological relevance of these coumarins remains poorly understood. Here, we show that the three enzymes leading to sideretin biosynthesis co-exist in Arabidopsis (Arabidopsis thaliana) epidermal and cortical cells and that the shift to fraxetin at alkaline pH depends on MYB72-mediated repression of CYTOCHROME P450, FAMILY 82, SUBFAMILY C, POLYPEPTIDE 4 (CYP82C4). In vitro, only fraxetin and sideretin can reduce part of the Fe(III) that they mobilize. We demonstrate that coumarin-mediated Fe(III) reduction is critical under acidic conditions, as fraxetin and sideretin can complement the Fe(III)-chelate reductase mutant ferric reduction oxidase 2 (fro2), and disruption of coumarin biosynthesis in fro2 plants impairs Fe acquisition similar to in the Fe(II) uptake-deficient mutant iron-regulated transporter 1 (irt1). Disruption of sideretin biosynthesis in a fro2 cyp82C4-1 double mutant revealed that sideretin is the dominant chemical reductant that functions with FRO2 to mediate Fe(II) formation for root uptake. At alkaline pH, Fe(III) reduction by coumarins becomes almost negligible but fraxetin still sustains high Fe(III) mobilization, suggesting that its main function is to provide chelated Fe(III) for FRO2. Our study indicates that strategy-I plants link sideretin and fraxetin biosynthesis and secretion to external pH to recruit distinct coumarin chemical activities to maximize Fe acquisition according to prevailing soil pH conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.