Evidence map›Paper›PMID 38015856›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2023

Effect of cardiopulmonary bypass on coagulation factors II, VII and X in a primate model: an exploratory pilot study.

Tomonari Shimoda, Chang Liu, Bryan J Mathis, Yukinobu Goto, Naohide Ageyama, Hideyuki Kato, Muneaki Matsubara, Tomohiro Ohigashi, Masahiko Gosho, Yasuyuki Suzuki and 1 more

Open access · diamondAbstract read
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In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Roller pump reverse flow-directed dynamic occlusiveness: towards precision in perfusion.Interdisciplinary cardiovascular and thoracic surgery · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tomonari ShimodaDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0001-5092-3127
Chang LiuDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Bryan J MathisInternational Medical Center, University of Tsukuba Hospital, Ibaraki, Japan.ORCID 0000-0002-9879-8289
Yukinobu GotoDepartment of Thoracic Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Naohide AgeyamaTsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Ibaraki, Japan.
Hideyuki KatoDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0001-9803-4871
Muneaki MatsubaraDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0001-7163-2724
Tomohiro OhigashiTsukuba Clinical Research & Development Organization, University of Tsukuba Hospital, Ibaraki, Japan.
Masahiko GoshoDepartment of Biostatistics, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Yasuyuki SuzukiDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0001-8073-0633
Yuji HiramatsuDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.ORCID 0000-0003-4323-1098
University of Tsukuba · JPUniversity of Tsukuba Hospital · JPNational Institute of Biomedical Innovation, Health and Nutrition · JP

Funding

Japan Society for the Promotion of Science B20390364
6 · The paper itself

Abstract

objectivesThe use of cardiopulmonary bypass (CPB) in cardiac surgery is a major risk factor for postoperative bleeding. We hypothesized that consumptive coagulopathy and haemodilution influence the coagulation factors; therefore, we aimed to estimate the activity profiles of coagulation factors II, VII and X during CPB circulation.

methodsA 120-min bypass was surgically established in cynomolgus monkeys (n = 7). Activities of coagulation factors II, VII and X were measured at 6 time points during the experiment (baseline, 0, 30, 60, 120 min of bypass and 60 min after bypass). To assess the influence of consumptive coagulopathy, the values were adjusted for haemodilution using the haematocrit values. Data were expressed as mean (standard deviation).

resultsActivities of coagulation factors decreased during the experiment. In particular, the activities for II, VII and X were decreased the most by 44.2% (5.0), 61.4% (4.3) and 49.0% (3.7) at 30 min following CPB initiation (P < 0.001, P < 0.001 and P < 0.001, respectively). Following adjustments for haemodilution, change magnitudes lessened but remained significant for factor VII. The adjusted concentration of factor VII was observed to decrease from the baseline to the initiation of bypass circulation.

conclusionsIn conclusion, coagulation factor II, VII and X concentrations decreased during CPB. Following adjustment for haemodilution, a decrease in concentration was observed with factor VII.

Indexed as

Cardiopulmonary bypassCoagulation factorsPostoperative bleeding

Identifiers

PMID38015856
PMCPMC10701202
OpenAlexW4389076148

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.