Evidence map›Paper›PMID 38015852›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells.

Jin Kumagai, Masahiro Kiuchi, Kota Kokubo, Hiroyuki Yagyu, Masahiro Nemoto, Kaori Tsuji, Ken Nagahata, Atsushi Sasaki, Takahisa Hishiya, Miki Onoue and 10 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  13. The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Jin Kumagai *Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-9305-0423
Masahiro Kiuchi *Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kota KokuboDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0001-6896-1981
Hiroyuki YagyuDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0003-4336-9919
Masahiro NemotoDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kaori TsujiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Ken NagahataDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Atsushi SasakiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0001-6127-7714
Takahisa HishiyaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Miki OnoueDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Rie ShinmiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yuri SonobeDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tomohisa IinumaDepartment of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Syuji YonekuraDepartment of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Jun ShingaLaboratory for Immunotherapy, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.ORCID 0000-0001-7077-304X
Toyoyuki HanazawaDepartment of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0001-9721-5662
Haruhiko KosekiDepartment of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Toshinori NakayamaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-1434-2007
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Kiyoshi HiraharaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-9128-9449
Chiba University · JPRIKEN Center for Integrative Medical Sciences · JPSapporo Medical University · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP20ek0410060Japan Agency for Medical Research and Development (AMED) JP20gm1210003Japan Agency for Medical Research and Development (AMED) JP22ek0410092JST FORREST program JPMJFR200RMinistry of Education, Culture, Sports, Science and Technology (MEXT) 17K08876Ministry of Education, Culture, Sports, Science and Technology (MEXT) 18K07164Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19K16683Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19K23858Ministry of Education, Culture, Sports, Science and Technology (MEXT) 20H03685Ministry of Education, Culture, Sports, Science and Technology (MEXT) 21H05121Ministry of Education, Culture, Sports, Science and Technology (MEXT) 22K15485Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP19H05650Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H05120
6 · The paper itself

Abstract

Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4

Indexed as

HypersensitivityTh2 CellsAnimalsCell DifferentiationGranzymesHumansInflammationInterleukin-5MiceSTAT3 Transcription FactorUbiquitin-Specific Peptidase 7GranzymesInterleukin-5STAT3 protein, humanSTAT3 Transcription FactorUbiquitin-Specific Peptidase 7USP7 protein, humanasthma, intractable allergic diseasegranzymepathogenic Th2 cellsignal transducers and activators of transcription (STAT)3ubiquitin specific protease 7 (USP7)

Identifiers

PMID38015852
PMCPMC10710068
OpenAlexW4389099942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.