ArticlePLOS global public health2023
Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network.
Article in PLOS global public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Molecular epidemiology of rotavirus causing diarrhea among under-five children after the introduction of rotavirus vaccines, Rotavac and Rotasiil, into the national immunization program of India.Virology journal · 2026Article
- Molecular detection and characterization of rotavirus A in wastewater from Morogoro, Tanzania.Journal of water and health · 2026Article
- Article
- Factors Associated with Rotavirus Positivity in Children with Acute Gastroenteritis in Jharkhand, India (2019-2023).Indian journal of pediatrics · 2025Article
- Surveillance and Genotypic Distribution of Rotavirus Diarrhea in Children with Acute Gastroenteritis in Dhanbad, Jharkhand, India.Indian journal of pediatrics · 2025Observational
- Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016-2020.Nature medicine · 2025Article
- [Global burden and predicted trends of diarrheal disease in children under five from 1990 to 2021].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Rotavirus Quantification and Genotyping in Wastewater: A Molecular Surveillance Study in Italy (2024-2025).Microorganisms · 2025Article
- Whole-genome analysis of rotavirus G1P[8] and other Wa-like strains in Mozambican children: evidence of genetic variations of pre-vaccine G1P[8] strains from Manhiça, Mozambique.Microbial genomics · 2025Article
- Article
- Global and regional trends in under-five diarrheal disease burden: impact of human development index and geographic disparities, 1990-2021.Gastroenterology and hepatology from bed to bench · 2025Article
- Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique.Scientific reports · 2024Article
- Article
- Study of rotavirus genotypes G and P in one Egyptian center-cross-sectional study.Italian journal of pediatrics · 2024Article
- Article
- Review
- Epidemiological, molecular, and evolutionary characteristics of G1P[8] rotavirus in China on the eve of RotaTeq application.Frontiers in cellular and infection microbiology · 2024Article
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Authors and funding
53 authors at 20 institutions in 18 countries.
Funding
Abstract
Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease burden but may also be changing the rotavirus genetic landscape and driving the emergence of new genotypes. We report genotype data of more than 16,000 rotavirus isolates from 40 countries participating in the Global Rotavirus Surveillance Network. Data from a convenience sample of children under five years of age hospitalized with acute watery diarrhea who tested positive for rotavirus were included. Country results were weighted by their estimated rotavirus disease burden to estimate regional genotype distributions. Globally, the most frequent genotypes identified after weighting were G1P[8] (31%), G1P[6] (8%) and G3P[8] (8%). Genotypes varied across WHO Regions and between countries that had and had not introduced rotavirus vaccine. G1P[8] was less frequent among African (36 vs 20%) and European (33 vs 8%) countries that had introduced rotavirus vaccines as compared to countries that had not introduced. Our results describe differences in the distribution of the most common rotavirus genotypes in children with diarrhea in low- and middle-income countries. G1P[8] was less frequent in countries that had introduced the rotavirus vaccine while different strains are emerging or re-emerging in different regions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.