ArticleEuropean journal of neurology2024
Optimal cardiovascular health is associated with slower cognitive decline.
Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Life's Simple 7, depressive symptoms, cognitive performance, and their associations with all-cause mortality among middle-aged urban adults.GeroScience · 2026Article
- Behavioral Components of Life's Essential 8 Are More Strongly Associated with Cognitive Function than Clinical Factors in Chinese Older Adults.International journal of behavioral medicine · 2026Article
- Association of the cumulative modified life's Essential 8 score with cognitive change: Results from two longitudinal cohorts.The journal of prevention of Alzheimer's disease · 2026Article
- Cardiovascular Health Among Employees of a Brazilian Tertiary Hospital Assessed by the Life's Essential 8 Score: A Cross-Sectional Pilot Study.Journal of clinical medicine · 2026Article
- Association of metabolic obesity phenotypes with cognitive decline in the ELSA-Brasil study.Diabetes, obesity & metabolism · 2026Article
- Gender-dependent association between cardiovascular health and cognitive function in chinese older adults: a community based cohort study.Cerebral circulation - cognition and behavior · 2026Article
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- DNA methylation signatures of Life's Essential 8 and their implications for dementia.Alzheimer's research & therapy · 2025Article
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
- The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study.Metabolites · 2025Article
- Targeting the Milieu in Neurodegenerative Disease: Time for "Imprecision Medicine"?Aging and disease · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Association between hypertension and dementia risk in low- and middle-income countries: A systematic review.JAR life · 2025Review
- Optimal cardiovascular health is associated with slower cognitive decline.European journal of neurology · 2024Article
- Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells.Biology · 2024Review
- Life's Essential 8™ and incident dementia in an urban cohort: Findings from the Northern Manhattan Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLife's Simple 7, a lifestyle and cardiovascular index associated with cognition, has been updated to Life's Essential 8 (LE8) to include sleep. LE8 has been related to cardiovascular outcomes but its association with cognition is unclear.
methodsIn this longitudinal analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), LE8 score was based on health behaviors (diet, physical activity, nicotine exposure, and sleep health) as well as health-related factors (body mass index, blood lipids, blood glucose, and blood pressure). Cognition was assessed in three waves, 4 years apart, using the Consortium to Establish a Registry for Alzheimer's Disease - Word List, semantic and phonemic verbal fluency, the Trail-Making Test B (TMT-B), and a global composite score. We used linear mixed-model analysis, inverse probability weighting, and interaction analysis.
resultsAt baseline, the mean age of the study cohort was 51.4 ± 8.9 years, 56% were women, and 53% were White. Higher baseline LE8 scores were associated with slower decline in global cognition (β = 0.001, 95% confidence interval [CI] 0.001, 0.002; p < 0.001), memory (β = 0.001, 95% CI 0.000, 0.002; p = 0.013), verbal fluency (β = 0.001, 95% CI 0.000, 0.002; p = 0.003), and TMT-B (β = 0.004, 95% CI 0.003, 0.005; p < 0.001). This association was mainly driven by LE8 health factors, particularly blood glucose and blood pressure. Age, sex, and race were modifiers of the association between LE8 and global cognitive decline (p < 0.001), suggesting it was more pronounced in older, male, and Black participants.
conclusionsHigher baseline LE8 scores were associated with slower global and domain-specific cognitive decline during 8 years of follow-up, mainly due to health factors such as blood glucose and blood pressure. Sociodemographic factors were modifiers of this association.
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