Evidence map›Paper›PMID 38015413›Full record

ArticleHormones (Athens, Greece)2024

Basal or stimulated thyroglobulin in evaluating response to treatment in papillary thyroid carcinoma? A retrospective cohort study.

Leticia Barreto, Deborah Cristina Goulart Ferreira, José Eduardo Corrente, Carlos Segundo Paiva Soares, Cristiano Claudino Oliveira, Simone Antunes Terra, Sonia Marta Moriguchi, Katia Hiromoto Koga, José Vicente Tagliarini, Gláucia Maria Ferreira da Silva Mazeto

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In one paragraph

Article in Hormones (Athens, Greece), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Leticia BarretoInternal Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0002-5340-1276
Deborah Cristina Goulart FerreiraInternal Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-5860-3187
José Eduardo CorrenteBiosciences Institute, Bioestatistics Department - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-5478-4996
Carlos Segundo Paiva SoaresOphthalmology, Otorhinolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0003-0121-9533
Cristiano Claudino OliveiraDepartment of Pathological Anatomy, AC Camargo Cancer Center, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6682-5230
Simone Antunes TerraPathology Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-7929-9014
Sonia Marta MoriguchiNuclear Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-5834-2714
Katia Hiromoto KogaNuclear Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0001-6223-7263
José Vicente TagliariniOphthalmology, Otorhinolaryngology and Head and Neck Surgery Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil.ORCID http://orcid.org/0000-0002-0869-724X
Gláucia Maria Ferreira da Silva MazetoInternal Medicine Department, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Brazil. g.mazeto@unesp.br.ORCID http://orcid.org/0000-0003-2129-7256
Universidade Estadual Paulista (Unesp) · BRAC Camargo Hospital · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/05011-7Institutional Scientific Initiation Scholarship Program from Sao Paulo State University - UNESP (PIBIC - Rectory) 36
6 · The paper itself

Abstract

objectiveIt is not clear whether response to initial treatment in papillary thyroid carcinoma (PTC) patients is best evaluated by measuring thyroglobulin (Tg) in the presence of levothyroxine (BTg) or when stimulated by elevated TSH (STg). The aim of this study was to evaluate whether response to therapy 1 year after initial treatment changes with the use of STg in relation to BTg in PTC patients treated with total thyroidectomy (TT) and radioiodine ( SUBJECTS AND

methodsThis is a retrospective study of 148 PTC patients submitted to TT and

resultsTwenty-eight patients (20.4%) presented change in response to therapy, with 17 of these (60.7%) presenting a worse response. Response using STg was 1.6 times better associated with proposed outcome [odds ratio (OR) = 4.61; confidence interval 95% (IC95%): 2.13-9.98] than with BTg (OR = 2.84; IC95%: 1.33-6.06).

conclusionResponse to therapy at 1 year using STg was altered in approximately 20% of cases and therefore proved to be a better predictor of excellent response in the last evaluation.

Indexed as

Carcinoma, PapillaryThyroid NeoplasmsHumansIodine RadioisotopesRetrospective StudiesThyroglobulinThyroid Cancer, PapillaryThyroidectomyIodine RadioisotopesThyroglobulinBiomarkers, TumorClinical evolutionPrognosisThyroglobulinThyroid cancer, Papillary

Identifiers

PMID38015413
OpenAlexW4389088618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.