Evidence map›Paper›PMID 38015329›Full record

ArticleDiscover nano2023

Monitoring levodopa oxidation and reduction reactions using surface plasmon resonance on a nanohole array electrode.

Hao-Fang Peng, Chih-Kang Chang, Rohit Gupta, Jian-Jang Huang

Abstract read
In one paragraph

Article in Discover nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Research Progress on Nanomaterials in SPR Sensors.Nanomaterials (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hao-Fang PengGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan.
Chih-Kang ChangGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan.
Rohit GuptaGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan.
Jian-Jang HuangGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan. jjhuang@ntu.edu.tw.

Funding

National Science and Technology Council 111-2221-E-002 -188 -MY3
6 · The paper itself

Abstract

The traditional method of monitoring the oxidation and reduction of biomedical materials usually relies on electrochemical (EC) measurement techniques. Here, we demonstrate a surface plasmon resonance (SPR) method to monitor the oxidation process. Using levodopa L-dopa as the target analyte, a nanohole sensing plate is embedded in the EC electrode to enhance the oxidation signal and generate SPR. Cyclic voltammetry (CV) measurement was first conducted to understand the baseline of EC response of L-Dopa. Then, the redox reactions were simultaneously monitored through SPR measurements during the CV voltage scan. The results showed that the limit of detection using traditional CV reached 1.47 μM while using EC-SPR, the limit of detection improved to 1.23 μM. Most importantly, we found a strong correlation between CV current profiles and the SPR reflection spectra. Our results facilitate detecting electrochemical reactions using an optical probing method.

Indexed as

BiosensorCyclic voltammetryL-DopaNanoholes arraySurface plasmon resonance

Identifiers

PMID38015329
PMCPMC10684436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.