Evidence map›Paper›PMID 38015290›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2024

Alpha-Mangostin and its nano-conjugates induced programmed cell death in Acanthamoeba castellanii belonging to the T4 genotype.

Usman Ahmed, Seng-Kai Ong, Kuan Onn Tan, Khalid Mohammed Khan, Naveed Ahmed Khan, Ruqaiyyah Siddiqui, Bader Saleem Alawfi, Ayaz Anwar

Abstract read
PubMed Publisher
In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 5 countries.

Usman AhmedDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
Seng-Kai OngDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
Kuan Onn TanDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Naveed Ahmed KhanMicrobiota Research Center, Istinye University, Istanbul, 34010, Turkey. naveed5438@gmail.com.
Ruqaiyyah SiddiquiMicrobiota Research Center, Istinye University, Istanbul, 34010, Turkey.
Bader Saleem AlawfiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, 42353, Madinah, Saudi Arabia.
Ayaz AnwarDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia. ayazanwarkk@yahoo.com.
Sunway University · MYIstinye University · TRInternational Center for Chemical and Biological Sciences · PKTaibah University · SA

Funding

Sunway University GRTIN-IRG-10-2022
6 · The paper itself

Abstract

Acanthamoeba are free living amoebae that are the causative agent of keratitis and granulomatous amoebic encephalitis. Alpha-Mangostin (AMS) is a significant xanthone; that demonstrates a wide range of biological activities. Here, the anti-amoebic activity of α-Mangostin and its silver nano conjugates (AMS-AgNPs) were evaluated against pathogenic A. castellanii trophozoites and cysts in vitro. Amoebicidal assays showed that both AMS and AMS-AgNPs inhibited the viability of A. castellanii dose-dependently, with an IC

Indexed as

Acanthamoeba castellaniiApoptosisXanthonesAmebicidesCell LineHumansKeratinocytesMembrane Potential, MitochondrialMetal NanoparticlesReactive Oxygen SpeciesSilverTrophozoitesAmebicidesmangostinReactive Oxygen SpeciesSilverXanthonesAcanthamoeba castellaniiAnti-amoebicApoptosisNext generation sequencingα-Mangostin

Identifiers

PMID38015290
OpenAlexW4389098076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.