ArticleJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2023
Greater medial proximal tibial slope is associated with bone marrow lesions in middle-aged women with early knee osteoarthritis.
Article in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Posterior cruciate ligament management in medial pivot total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis.Archives of orthopaedic and trauma surgery · 2024Pooled it
- The posterior tibial slope modifies the diagnostic utility of posterior shiny-corner lesions in medial meniscus posterior root tears.Journal of experimental orthopaedics · 2026Article
- Association between body composition, knee synovial effusion, and serum glutamate in middle-aged women with knee osteoarthritis: a cross-sectional study.Scientific reports · 2026Article
- Subchondral bone marrow aspirate concentrate injection improves clinical outcomes and reduces bone marrow lesions in knee osteoarthritis: 12-month retrospective analysis.Journal of orthopaedic surgery and research · 2026Article
- Steeper medial posterior tibial slope is associated with medial meniscal extrusion and early-onset knee osteoarthritis in middle-aged Japanese women: A longitudinal cohort study.Journal of experimental orthopaedics · 2026Article
- Quantitative analysis of bony and soft tissue contributions to varus deformity across knee osteoarthritis stages.Journal of experimental orthopaedics · 2026Article
- Sex-specific patterns and limited bilateral symmetry in coronal knee alignment: Insights from the modified coronal plane alignment of the knee classification.Osteoarthritis and cartilage open · 2026Article
- Medial joint line obliquity and medial meniscus tear were associated with medial meniscal extrusion: A case-control study.Journal of experimental orthopaedics · 2025Article
- Review
- Mid-term patient-reported outcomes are inferior in opening-wedge high tibial osteotomy patients with untreated medial meniscus posterior root tear.Journal of experimental orthopaedics · 2024Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBone marrow lesion (BML) is an important magnetic resonance finding (MRI) finding that predicts knee osteoarthritis. The purpose of this study was to investigate the influence of proximal tibial morphology on BML, including the spreading root sign (SRS), in women without radiographic knee osteoarthritis (OA). It was hypothesized that varus alignment and a greater posterior tibial slopes (PTS) are associated with BML. MATERIALS AND
methodsA total of 359 female volunteers without knee OA who were participants in the Iwaki Health Promotion Project in 2017 or 2019 were enrolled. Participants were divided into the non-OA and early knee OA (EKOA) groups based on the Luyten's classification criteria. The presence of pathological cartilage lesions, BMLs, attritions, meniscal lesions and effusions was scored on T2-weighted fat-suppressed magnetic resonance imaging (MRI) according to the Whole-Organ MRI Scoring system. The medial proximal tibial angle (MPTA) and medial and lateral PTS (MPTS and LPTS, respectively) were measured. Regression and receiver operating characteristic (ROC) analyses were performed to reveal the relationship between BMLs and proximal tibial morphological parameters.
resultsOf the 359 participants, 54 (15%) were classified as having EKOA. The prevalence of cartilage lesions, BMLs, attritions, meniscal lesions and effusions was higher in the EKOA group than in the non-OA group. The two groups had no significant difference in the proximal tibial parameters. Regression analysis revealed that age and a smaller MPTA were associated with BML in both groups. Attrition (p = 0.029) and the MPTS (p = 0.025) were positively associated with BML in the EKOA group.
conclusionThe prevalence of BMLs was higher in women with EKOA and correlated with the varus and greater posterior slopes in those without radiographic knee OA. LEVEL OF EVIDENCE: Level III, retrospective case-control study.
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