Evidence map›Paper›PMID 38015204›Full record

ArticleeLife2023

Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis.

Takeru Kondo, Annie Gleason, Hiroko Okawa, Akishige Hokugo, Ichiro Nishimura

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  8. Inflammasome targeting for periodontitis prevention is sex dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. CD81eLife · 2025
    Article
  11. Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Takeru KondoWeintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, United States.ORCID 0009-0002-1560-1741
Annie GleasonWeintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, United States.
Hiroko OkawaWeintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, United States.
Akishige HokugoWeintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, United States.ORCID 0000-0002-7097-3364
Ichiro NishimuraWeintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, United States.ORCID 0000-0002-3749-9445
Tohoku University · JPGenomics (United Kingdom) · GB

Funding

Competitive Equilibrium-based Displacement of Bisphosphonates as Novel Therapeutic Approach for BRONJR44DE025524 · NIDCR · BIOVINC, LLC · PI EBETINO, FRANK H. · 2017 to 2018
$2.2M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION PROJECTSC06RR014529 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARK, NO-HEE · 1999 to 1999
–
NCRR NIH HHS C06 RR014529NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R01DE022550NIDCR NIH HHS R44 DE025524NIDCR NIH HHS R44DE025524
6 · The paper itself

Abstract

Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to be delineated. Here, we report a unique fibroblast subpopulation

Indexed as

AscomycotaBone ResorptionPeriodontitisAnimalsDisease Models, AnimalFibroblastsImmunity, InnateInflammationLymphocytesMiceTranscriptomegingival fibroblastimmunologyinflammationmousemouse periodontitis modelsoral barrier immunologysingle-cell RNA sequencing

Identifiers

PMID38015204
PMCPMC10684155
OpenAlexW4379141811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.