Evidence map›Paper›PMID 38014948›Full record

ArticleInfection and immunity2024

IL-17 receptor A functions to help maintain barrier integrity and limit activation of immunopathogenic response to

Lee C Brackman, Beverly R E A Dixon, Margaret Bernard, Frank Revetta, Rebecca P Cowell, Leslie M Meenderink, M Kay Washington, M Blanca Piazuelo, Holly M Scott Algood

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026
    Review
  3. Frontiers in immunology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lee C BrackmanDivision of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0009-0003-2142-9658
Beverly R E A DixonDivision of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Margaret BernardDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Frank RevettaDivision of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rebecca P CowellDivision of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Leslie M MeenderinkDivision of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
M Kay WashingtonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
M Blanca PiazueloDivision of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Holly M Scott AlgoodDivision of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3735-4649
Vanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
The role of Th17 cytokines in H.pylori infectionI01BX000915 · VA · VETERANS HEALTH ADMINISTRATION · PI HOLLY Marie Scott ALGOOD · 2011 to 2026
–
The role of enterocyte apical structure in inflammatory bowel disease pathogenesisIK2BX004885 · VA · VETERANS HEALTH ADMINISTRATION · PI MEENDERINK, LESLIE M · 2020 to 2024
–
BLRD VA I01 BX000915BLRD VA IK2 BX004885NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Activation of Th17 cell responses, including the production of IL-17A and IL-21, contributes to host defense and inflammatory responses by coordinating adaptive and innate immune responses. IL-17A and IL-17F signal through a multimeric receptor, which includes the IL-17 receptor A (IL-17RA) subunit and the IL-17RC subunit. IL-17RA is expressed by many cell types, and data from previous studies suggest that loss of IL-17 receptor is required to limit immunopathology in the

Indexed as

GastritisHelicobacter InfectionsHelicobacter pyloriAnimalsGastric MucosaImmunoglobulin AInflammationInterleukin-17MiceReceptors, Interleukin-17Immunoglobulin AInterleukin-17Receptors, Interleukin-17gastric dysplasiaHelicobacter pyloriimmunoglobulin Ainterleukin 17mucinT lymphocytes

Identifiers

PMID38014948
PMCPMC10790819
OpenAlexW4389085358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.