ArticleJournal of the American Heart Association2023
Early Utilization of Mechanical Circulatory Support in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The National Cardiogenic Shock Initiative.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03677180 (National Cardiogenic Shock Initiative), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Cardiogenic Shock Initiative
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) in 2024.Cardiovascular intervention and therapeutics · 2024Guideline
- Infections following temporary mechanical circulatory support in cardiogenic shock: Incidence, associations, and outcomes.JHLT open · 2026Article
- Mechanical circulatory support for haemodynamic protection in patients with heart failure during non-cardiac surgery.American heart journal plus : cardiology research and practice · 2026Article
- Hospital-Level Variations in Outcomes and Readmissions Among Patients With STEMI and Cardiogenic Shock Receiving Mechanical Circulatory Support: Insights From a National Cohort.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Temporary Mechanical Circulatory Support in Patients in Cardiogenic Shock Requiring Cardiac Surgery: Protected Cardiac Surgery Concept.Journal of clinical medicine · 2026Review
- Implementation of a standardized Impella-specific management pathway in cardiogenic shock.Journal of intensive care · 2026Article
- Simple risk stratification of patients with ST-segment elevation myocardial infarction: based on the modified DanGer shock trial-derived criteria assessed at initial emergency room presentation.Heart and vessels · 2026Article
- Preoperative extracorporeal membrane oxygenation is associated with improved outcomes in emergent surgical pulmonary embolectomy.General thoracic and cardiovascular surgery · 2026Article
- Mechanical Support in Myocardial Infarction Complicated by Cardiogenic Shock: What Have We Learned from Trials?Journal of clinical medicine · 2026Review
- Optimizing protected PCI strategies in the setting of chronic kidney disease and advanced coronary artery disease: a clinical case-based discussion.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Article
- Initial intra-aortic balloon pump versus Impella support strategies and short-term outcomes in acute myocardial infarction complicated by cardiogenic shock: a MIMIC-IV cohort study.BMC cardiovascular disorders · 2026Article
- Campylobacter jejuni-Associated Perimyocarditis in 53-Year-Old Male With Chest Pain and Watery Diarrhea.JACC. Case reports · 2026Article
- CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) in 2026.Cardiovascular intervention and therapeutics · 2026Article
- Cardiogenic Shock: Clinical Management, Outcomes and Future Directions.Journal of cardiovascular development and disease · 2026Review
- Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry.ESC heart failure · 2026Article
- Venoarterial extracorporeal membrane oxygenation (VA-ECMO) in high-risk (HR) percutaneous coronary intervention (PCI).Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- DanGer shock criteria and outcomes in acute myocardial infarction-related cardiogenic shock treated with Impella: the J-PVAD registry.European heart journal · 2026Article
- Experts' recommendations for the management of adult patients with cardiogenic shock.Annals of intensive care · 2026Article
- Timing of intervention in cardiogenic shock management: A systematic review and network meta-analysis.Journal of education and health promotion · 2026Review
Corrections and comments
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Authors and funding
33 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute myocardial infarction complicated by cardiogenic shock (AMI-CS) is associated with significant morbidity and mortality. Mechanical circulatory support (MCS) devices increase systemic blood pressure and end organ perfusion while reducing cardiac filling pressures. METHODS AND
resultsThe National Cardiogenic Shock Initiative (NCT03677180) is a single-arm, multicenter study. The purpose of this study was to assess the feasibility and effectiveness of utilizing early MCS with Impella in patients presenting with AMI-CS. The primary end point was in-hospital mortality. A total of 406 patients were enrolled at 80 sites between 2016 and 2020. Average age was 64±12 years, 24% were female, 17% had a witnessed out-of-hospital cardiac arrest, 27% had in-hospital cardiac arrest, and 9% were under active cardiopulmonary resuscitation during MCS implantation. Patients presented with a mean systolic blood pressure of 77.2±19.2 mm Hg, 85% of patients were on vasopressors or inotropes, mean lactate was 4.8±3.9 mmol/L and cardiac power output was 0.67±0.29 watts. At 24 hours, mean systolic blood pressure improved to 103.9±17.8 mm Hg, lactate to 2.7±2.8 mmol/L, and cardiac power output to 1.0±1.3 watts. Procedural survival, survival to discharge, survival to 30 days, and survival to 1 year were 99%, 71%, 68%, and 53%, respectively.
conclusionsEarly use of MCS in AMI-CS is feasible across varying health care settings and resulted in improvements to early hemodynamics and perfusion. Survival rates to hospital discharge were high. Given the encouraging results from our analysis, randomized clinical trials are warranted to assess the role of utilizing early MCS, using a standardized, multidisciplinary approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.