Evidence map›Paper›PMID 38014669›Full record

ArticleJournal of the American Heart Association2023

Association of Life's Essential 8 With Cardiovascular Disease and Mortality: The Framingham Heart Study.

Athanasios Rempakos, Brenton Prescott, Gary F Mitchell, Ramachandran S Vasan, Vanessa Xanthakis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  17. Lifestyle factors and cardiometabolic risk.Chinese medical journal · 2026
    Review
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Athanasios RempakosMinneapolis Heart Institute Foundation Minneapolis MN.ORCID 0000-0002-2683-5255
Brenton PrescottSection of Preventive Medicine and Epidemiology, Department of Medicine Boston University School of Medicine Boston MA.ORCID 0000-0002-3805-9070
Gary F MitchellCardiovascular Engineering, Inc Norwood MA.ORCID 0000-0001-5643-3145
Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine Boston University School of Medicine Boston MA.ORCID 0000-0001-7357-5970
Vanessa XanthakisSection of Preventive Medicine and Epidemiology, Department of Medicine Boston University School of Medicine Boston MA.ORCID 0000-0002-7352-621X
Boston University · USMinneapolis Heart Institute Foundation · USNorwood Hospital · US

Funding

NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001I
6 · The paper itself

Abstract

backgroundThe association of the American Heart Association's updated cardiovascular health score, the Life's Essential 8 (LE8), with cardiovascular disease (CVD) and death is not described in the FHS (Framingham Heart Study). METHODS AND

resultsWe evaluated Framingham Offspring participants at examinations 2 and 6 (n=2888 and 1667; and mean age, 44 and 57 years, respectively), free of CVD with information on LE8 components. Using age-sex-adjusted Cox models, we related LE8 and its change (examination 2 to examination 6) with CVD and death risk and compared associations with those of the Life's Simple 7 score. Mean LE8 score at examination 2 was 67 points (minimum, 26 points; maximum, 100 points). At both examinations, participants were reclassified to a different cardiovascular health status, depending on which method (LE8 versus Life's Simple 7) was used (60% of participants in ideal Life's Simple 7 status were in intermediate LE8 category). On follow-up after examination 2 (median, 30 and 33 years for CVD and death, respectively), we observed 966 CVD events, and 1195 participants died. Participants having LE8≥68 (sample median) were at lower CVD and death risk compared with those with LE8<68 (examination 2: CVD hazard ratio [HR], 0.47 [95% CI, 0.41-0.54]; death HR, 0.55 [95% CI, 0.49-0.62]; all

conclusionsFurther studies are warranted to elucidate whether the LE8 score is a better marker of CVD and death risk, compared with Life's Simple 7 score.

Indexed as

Cardiovascular DiseasesAdultHeartHumansLongitudinal StudiesMiddle AgedRisk FactorsUnited StatesAmerican Heart Associationcardiovascular diseaseideal cardiovascular healthLife's Essential 8

Identifiers

PMID38014669
PMCPMC10727315
OpenAlexW4389087492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.