Evidence map›Paper›PMID 38014662›Full record

ArticleJournal of the American Heart Association2023

NT-proBNP Mediates the Association Between FGF23 and All-Cause Mortality in Individuals With Type 2 Diabetes.

Amarens van der Vaart, Stephan J L Bakker, Gozewijn D Laverman, Peter R van Dijk, Martin H de Borst

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amarens van der VaartDepartment of Internal Medicine, Division of Nephrology University Medical Center Groningen, University of Groningen Groningen The Netherlands.ORCID 0000-0002-9149-184X
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology University Medical Center Groningen, University of Groningen Groningen The Netherlands.ORCID 0000-0003-3356-6791
Gozewijn D LavermanDivision of Nephrology, Department of Internal Medicine Ziekenhuisgroep Twente Hengelo The Netherlands.ORCID 0000-0002-8716-7115
Peter R van DijkDepartment of Internal Medicine, Division of Endocrinology University Medical Center Groningen, University of Groningen Groningen The Netherlands.ORCID 0000-0002-9702-6551
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology University Medical Center Groningen, University of Groningen Groningen The Netherlands.ORCID 0000-0002-4127-8733
University Medical Center Groningen · NLZiekenhuis Groep Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFGF23 (fibroblast growth factor 23) is associated with a higher mortality risk in type 2 diabetes, but the mechanism is unclear. We aimed to study whether NT-proBNP (N-terminal pro-brain natriuretic peptide) mediates the association between FGF23 and mortality. METHODS AND

resultsWe analyzed C-terminal FGF23 and NT-proBNP levels in 399 patients with type 2 diabetes. Cox regression analyses were performed, followed by mediation analyses using Structural Equation Modeling. During follow-up of 9.2 [7.6-11.3] years, 117 individuals died. FGF23 was associated with all-cause mortality, independent of potential confounders (fully adjusted hazard ratio [HR], 2.32 [95% CI, 1.21-4.43],

conclusionsThese findings suggest that a higher FGF23 level is associated with increased mortality in individuals with type 2 diabetes through an effect on volume homeostasis.

Indexed as

Diabetes Mellitus, Type 2BiomarkersHumansNatriuretic Peptide, BrainPeptide FragmentsPrognosisBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)FGF23NT‐proBNPtype 2 diabetesvolume homeostasis

Identifiers

PMID38014662
PMCPMC10727346
OpenAlexW4389087353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.