Evidence map›Paper›PMID 38014550›Full record

ArticleCirculation2024

Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events.

Feitong Wu, Markus Juonala, David R Jacobs, Stephen R Daniels, Mika Kähönen, Jessica G Woo, Alan R Sinaiko, Jorma S A Viikari, Lydia A Bazzano, Trudy L Burns and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 4 countries.

Feitong WuMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (F.W., A.J.V., T.D., C.G.M.).ORCID 0000-0003-3753-974X
Markus JuonalaDepartment of Medicine, University of Turku, Finland (M.J., J.S.J.V.).ORCID 0000-0001-9498-364X
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (D.R.J.).ORCID 0000-0002-7232-0543
Stephen R DanielsDepartment of Pediatrics, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora (S.R.D.).ORCID 0000-0001-5520-6952
Mika KähönenFaculty of Medicine and Health Technology, Tampere University, Finland (M.K.).ORCID 0000-0002-4510-7341
Jessica G WooDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, OH (J.G.W.).ORCID 0000-0003-3644-8432
Alan R SinaikoUniversity of Minnesota Medical School, Minneapolis (A.R.S.).ORCID 0000-0001-8277-3493
Jorma S A ViikariDepartment of Medicine, University of Turku, Finland (M.J., J.S.J.V.).ORCID 0000-0001-6452-010X
Lydia A BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (L.A.B.).ORCID 0000-0002-8958-1352
Trudy L BurnsDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City (T.L.B.).ORCID 0000-0001-5639-3059
Julia SteinbergerDepartment of Pediatrics, University of Minnesota School of Medicine, Minneapolis (J.S.).ORCID 0000-0002-2892-8594
Elaine M UrbinaThe Heart Institute, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, OH (E.M.U.).ORCID 0000-0002-5640-6777
Alison J VennMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (F.W., A.J.V., T.D., C.G.M.).ORCID 0000-0001-7090-1398
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Finland (O.T.R., C.G.M.).ORCID 0000-0001-9365-3702
Terence DwyerMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (F.W., A.J.V., T.D., C.G.M.).ORCID 0000-0002-2091-7663
Costan G MagnussenMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (F.W., A.J.V., T.D., C.G.M.).ORCID 0000-0002-6238-5730
University of Tasmania · AUCincinnati Children's Hospital Medical Center · USUniversity of Minnesota · USUniversity of Turku · FIChildren's Hospital Colorado · USTampere University of Applied Sciences · FITulane University · USTurku University of Applied Sciences · FIUniversity of Iowa · USUniversity of Minnesota Medical Center · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
INSULIN AND BLOOD PRESSURE CHANGE DURING ADOLESCENCER01HL052851 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SINAIKO, ALAN R. · 1995 to 2007
$5.0M
EPIDEMIOLOGY OF CAROTID ARTERY ATHEROSCLEROSIS IN YOUTHR01HL054730 · NHLBI · UNIVERSITY OF IOWA · PI DAVIS, PATRICIA HELEN · 1995 to 2008
$4.7M
Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
VISCERAL ADIPOSITY AND CVD RISK IN WOMENR01HL066430 · NHLBI · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI KIMBALL, THOMAS R · 2001 to 2005
$3.3M
ARTERIAL ENDOTHELIAL FUNCTION--AN EPIDEMIOLOGIC STUDYR01HL061857 · NHLBI · UNIVERSITY OF IOWA · PI BURNS, TRUDY L · 2005 to 2008
$3.0M
VASCULAR CALCIUM--AN EPIDEMIOLOGIC STUDYR01HL048050 · NHLBI · UNIVERSITY OF IOWA · PI MAHONEY, LARRY T · 1992 to 2004
$3.0M
Cardiovascular Risk and Insulin Resistance: Age 7-40R01DK072124 · NIDDK · UNIVERSITY OF MINNESOTA · PI STEINBERGER, JULIA · 2007 to 2011
$3.0M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
GENETIC EPIDEMIOLOGY OF CHILDHOOD OBESITYR01HD029569 · NICHD · UNIVERSITY OF IOWA · PI BURNS, TRUDY L · 1992 to 2003
$2.6M
European Research CouncilNHLBI NIH HHS K23 HL004000NHLBI NIH HHS N01 HC055025NHLBI NIH HHS P50 HL015103NHLBI NIH HHS R01 HL002942NHLBI NIH HHS R01 HL019877NHLBI NIH HHS R01 HL020124NHLBI NIH HHS R01 HL033973NHLBI NIH HHS R01 HL034659NHLBI NIH HHS R01 HL035600NHLBI NIH HHS R01 HL048050NHLBI NIH HHS R01 HL052851NHLBI NIH HHS R01 HL052911NHLBI NIH HHS R01 HL054730NHLBI NIH HHS R01 HL061857NHLBI NIH HHS R01 HL062394NHLBI NIH HHS R01 HL066430NHLBI NIH HHS R01 HL121230NHLBI NIH HHS U01 HL038844NHLBI NIH HHS U01 HL084891NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG041200NIA NIH HHS R01 AG062309NIA NIH HHS R03 AG060619NIA NIH HHS R33 AG057983NICHD NIH HHS R01 HD013374NICHD NIH HHS R01 HD029569NICHD NIH HHS R01 HD032194NICHD NIH HHS R01 HD069587NICHD NIH HHS R03 HD047247NICHD NIH HHS R03 HD062783NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK072124NIDDK NIH HHS R21 DK085363NIEHS NIH HHS R01 ES021724NIGMS NIH HHS R01 GM028719NIH HHS NIH HL121230
6 · The paper itself

Abstract

backgroundAlthough low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non-high-density lipoprotein cholesterol (non-HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk. We examined the associations of childhood non-HDL-C and LDL-C levels with adult ASCVD events and determined whether non-HDL-C has better utility than LDL-C in predicting adult ASCVD events.

methodsThis prospective cohort study included 21 126 participants from the i3C Consortium (International Childhood Cardiovascular Cohorts). Proportional hazards regressions were used to estimate the risk for incident fatal and fatal/nonfatal ASCVD events associated with childhood non-HDL-C and LDL-C levels (age- and sex-specific

resultsAfter an average follow-up of 35 years, 153 fatal ASCVD events occurred in 21 126 participants (mean age at childhood visits, 11.9 years), and 352 fatal/nonfatal ASCVD events occurred in a subset of 11 296 participants who could be evaluated for this outcome. Childhood non-HDL-C and LDL-C levels were each associated with higher risk of fatal and fatal/nonfatal ASCVD events (hazard ratio ranged from 1.27 [95% CI, 1.14-1.41] to 1.35 [95% CI, 1.13-1.60] per unit increase in the risk factor

conclusionsChildhood non-HDL-C and LDL-C levels are associated with ASCVD events in midlife. Non-HDL-C is better than LDL-C in predicting adult ASCVD events, particularly among individuals who had normal LDL-C but elevated non-HDL-C. These findings suggest that both non-HDL-C and LDL-C are useful in identifying children at higher risk of ASCVD events, but non-HDL-C may provide added prognostic information when it is discordantly higher than the corresponding LDL-C and has the practical advantage of being determined without a fasting sample.

Indexed as

AtherosclerosisCardiovascular DiseasesAdultChildCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansLipoproteinsMaleProspective StudiesRisk FactorsCholesterolCholesterol, HDLCholesterol, LDLLipoproteinsatherosclerosisepidemiologylipoproteinslongitudinal studiesrisk assessmentrisk factors

Identifiers

PMID38014550
PMCPMC12955349
OpenAlexW4389090040

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.