Evidence map›Paper›PMID 38014355›Full record

ArticlebioRxiv : the preprint server for biology2023

Water inside the selectivity filter of a K

Matthew J Ryan, Lujia Gao, Francis I Valiyaveetil, Alexei A Kananenka, Martin T Zanni

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Matthew J RyanDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-1633-9087
Lujia GaoDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
Francis I ValiyaveetilDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-3387-8018
Alexei A KananenkaDepartment of Physics and Astronomy, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-9422-7203
Martin T ZanniDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0001-7191-9768
Oregon Health & Science University · USUniversity of Wisconsin–Madison · USUniversity of Delaware · US

Funding

A new perspesective on ion conductance and structural dynamics of ion channels using 2D IRR01GM135936 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ZANNI, MARTIN T · 2020 to 2025
$1.7M
PowerEdge XE8640 GPU cluster for molecular dynamics simulations and machine learning computational vibrational spectroscopy of ion channelsR35GM150963 · NIGMS · UNIVERSITY OF DELAWARE · PI Alexei Kananenka · 2023 to 2026
$1.3M
NIGMS NIH HHS R01 GM135936NIGMS NIH HHS R35 GM150963
6 · The paper itself

Abstract

Water inside biological ion channels regulates the key properties of these proteins such as selectivity, ion conductance, and gating. In this Article we measure the picosecond spectral diffusion of amide I vibrations of an isotope labeled KcsA potassium channel using two-dimensional infrared (2D IR) spectroscopy. By combining waiting time (100 - 2000 fs) 2D IR measurements of the KcsA channel including

Identifiers

PMID38014355
PMCPMC10680850
OpenAlexW4388751648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.