Evidence map›Paper›PMID 38014325›Full record

ArticlebioRxiv : the preprint server for biology2024

Environment-independent distribution of mutational effects emerges from microscopic epistasis.

Sarah Ardell, Alena Martsul, Milo S Johnson, Sergey Kryazhimskiy

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sarah ArdellDepartment of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093.
Alena MartsulDepartment of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093.
Milo S JohnsonDepartment of Integrative Biology, University of California Berkeley, Berkeley, CA 94720.
Sergey KryazhimskiyDepartment of Ecology, Behavior and Evolution, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-9128-8705
University of California San Diego · USLawrence Berkeley National Laboratory · US

Funding

Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Characterizing variation in the local structure of fitness landscapes to assess the predictability of evolutionR01GM137112 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KRYAZHIMSKIY, SERGEY A. · 2020 to 2023
$1.2M
Empirical and Theoretical Studies of Adaptive Mutations in Microbes and Their Evolutionary ConsequencesR35GM153242 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sergey A. Kryazhimskiy · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM137112NIGMS NIH HHS R35 GM153242NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

Predicting how new mutations alter phenotypes is difficult because mutational effects vary across genotypes and environments. Recently discovered global epistasis, where the fitness effects of mutations scale with the fitness of the background genotype, can improve predictions, but how the environment modulates this scaling is unknown. We measured the fitness effects of ~100 insertion mutations in 42 strains of

Identifiers

PMID38014325
PMCPMC10680819
OpenAlexW4388811497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.