Evidence map›Paper›PMID 38014320›Full record

ArticlebioRxiv : the preprint server for biology2023

A mouse model of ZTTK syndrome reveals indispensable SON functions in organ development and hematopoiesis.

Lana Vukadin, Bohye Park, Mostafa Mohamed, Huashi Li, Amr Elkholy, Alex Torrelli-Diljohn, Jung-Hyun Kim, Kyuho Jeong, James M Murphy, Caitlin A Harvey and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Lana VukadinDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Bohye ParkDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mostafa MohamedDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Huashi LiDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amr ElkholyDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Alex Torrelli-DiljohnDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Jung-Hyun KimMetastasis Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi-do, Korea.
Kyuho JeongDepartment of Medicine, College of Medicine, Dongguk University, Gyeongju, Korea.
James M MurphyDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Caitlin A HarveyDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sophia DunlapDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Leah GehrsDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Hanna LeeDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Hyung-Gyoon KimDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Seth N LeeDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Denise StanfordDepartment of Medicine, Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Robert A BarringtonDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Jeremy B FooteDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Anna G SoraceDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Robert S WelnerO'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Blake E HildrethDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ssang-Taek Steve LimDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Eun-Young Erin AhnDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USDongguk University · KRNational Cancer Center · KRUniversity of South Alabama · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI George Martin Solomon · 2007 to 2026
$23.0M
Genetic and molecular basis of hematopoietic abnormalities in ZTTK syndromeR01HL168659 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erin Eun-Young Ahn · 2023 to 2026
$2.1M
Nuclear FAK-mediated VSMC differentiation via epigenetic reprograming invascular diseasesR01HL158800 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIM, STEVE · 2022 to 2025
$1.9M
SON-mediated RNA splicing in glioblastomaR01CA236911 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHN, ERIN EUN-YOUNG · 2020 to 2024
$1.8M
SON-mediated gene expression and leukemiaR01CA190688 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI AHN, ERIN EUN-YOUNG · 2016 to 2021
$1.7M
FAK regulation of cholesterol influx and efflux in foam cellsR01HL158875 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LIM, STEVE · 2021 to 2024
$1.5M
Macrophage and osteoclast specific targeting for the prevention and treatment of breast cancer bone metastasisK01OD026527 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HILDRETH, BLAKE EASON · 2018 to 2022
$634k
NCATS NIH HHS UL1 TR001417NCI NIH HHS R01 CA190688NCI NIH HHS R01 CA236911NHLBI NIH HHS R01 HL158800NHLBI NIH HHS R01 HL158875NHLBI NIH HHS R01 HL168659NIDDK NIH HHS P30 DK072482NIH HHS K01 OD026527
6 · The paper itself

Abstract

Rare diseases are underrepresented in biomedical research, leading to insufficient awareness. Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is a rare disease caused by genetic alterations that result in heterozygous loss-of-function of SON. While ZTTK syndrome patients suffer from numerous symptoms, the lack of model organisms hamper our understanding of both SON and this complex syndrome. Here, we developed

Identifiers

PMID38014320
PMCPMC10680872
OpenAlexW4388814065

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.