Evidence map›Paper›PMID 38014294›Full record

ArticlebioRxiv : the preprint server for biology2023

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration.

Fátima C Pereira, Xiaowei Ge, Jannie Munk Kristensen, Rasmus H Kirkegaard, Klara Maritsch, Yifan Zhu, Marie Decorte, Bela Hausmann, David Berry, Kenneth Wasmund and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 5 countries.

Fátima C PereiraCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-1288-6481
Xiaowei GeDepartment of Electrical & Computer Engineering, Boston University, Boston, Massachusetts, USA.ORCID 0000-0001-8938-9304
Jannie Munk KristensenCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0001-7471-7934
Rasmus H KirkegaardCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0003-3349-3617
Klara MaritschCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
Yifan ZhuDepartment of Chemistry, Boston University, Boston, Massachusetts, USA.
Marie DecorteCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
Bela HausmannJoint Microbiome Facility of the Medical University of Vienna and the University of Vienna, Vienna, Austria.ORCID 0000-0002-0846-1202
David BerryCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-8997-608X
Kenneth WasmundCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0001-6706-7291
Arno SchintlmeisterCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-1146-0032
Thomas BoettcherCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
Ji-Xin ChengDepartment of Electrical & Computer Engineering, Boston University, Boston, Massachusetts, USA.
Michael WagnerCentre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
University of Vienna · ATBoston University · USVinUniversity · VN

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
Advanced laser scanning confocal microscope for multiple usersS10OD024993 · OD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2018 to 2018
$448k
Austrian Science Fund FWF ZK 57NIAID NIH HHS R01 AI141439NIGMS NIH HHS R35 GM136223NIH HHS S10 OD024993
6 · The paper itself

Abstract

Increasing evidence shows that many human-targeted drugs alter the gut microbiome, leading to implications for host health. However, much less is known about the mechanisms by which drugs target the microbiome and how drugs affect microbial function. Here we combined quantitative microbiome profiling, long-read metagenomics, stable isotope probing and single-cell chemical imaging to investigate the impact of two widely prescribed nervous system-targeted drugs on the gut microbiome.

Identifiers

PMID38014294
PMCPMC10680583
OpenAlexW4388615974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.