Evidence map›Paper›PMID 38014262›Full record

ArticlebioRxiv : the preprint server for biology2024

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses.

Cody J Warren, Arturo Barbachano-Guerrero, Vanessa L Bauer, Alex C Stabell, Obaiah Dirasantha, Qing Yang, Sara L Sawyer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cody J WarrenBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Arturo Barbachano-GuerreroBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.ORCID 0000-0001-7483-839X
Vanessa L BauerBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Alex C StabellBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Obaiah DirasanthaBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Qing YangBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Sara L SawyerBioFrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.ORCID 0000-0002-6965-1085
University of Colorado Boulder · US

Funding

Breaking the Barrier to an HIV VaccineDP1AI175471 · NIAID · UNIVERSITY OF COLORADO · PI Sara Sawyer · 2022 to 2026
$5.5M
Hunting the HIV-1 UnicornDP1DA046108 · NIDA · UNIVERSITY OF COLORADO · PI SAWYER, SARA · 2018 to 2022
$4.5M
Characterizing Host-Virus Interactions in a New HIV Model OrganismR01OD034046 · OD · UNIVERSITY OF COLORADO · PI Sara Sawyer · 2022 to 2026
$3.6M
Host genetic barriers to virus spilloverR01AI137011 · NIAID · UNIVERSITY OF COLORADO · PI SAWYER, SARA · 2018 to 2022
$2.1M
FACSAria Fusion Cell SorterS10OD021601 · OD · UNIVERSITY OF COLORADO · PI LIU, XUEDONG · 2016 to 2016
$599k
Investigating CD4 as a species-specific barrier to transmitted/founder HIV-1 infectionF32GM125442 · NIGMS · UNIVERSITY OF COLORADO · PI WARREN, CODY JAY · 2018 to 2019
$120k
NIAID NIH HHS DP1 AI175471NIAID NIH HHS R01 AI137011NIDA NIH HHS DP1 DA046108NIGMS NIH HHS F32 GM125442NIH HHS R01 OD034046NIH HHS S10 OD021601
6 · The paper itself

Abstract

Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir, but the spillover did not occur directly from monkeys to humans. Instead, a key event was the introduction of SIVs into great apes, which then set the stage for infection of humans. Here, we investigate the role of the lentiviral entry receptor, CD4, in this key and fateful event in the history of SIV/HIV emergence. First, we reconstructed and tested ancient forms of CD4 at two important nodes in ape speciation, both prior to the infection of chimpanzees and gorillas with these viruses. These ancestral CD4s fully supported entry of diverse SIV isolates related to the viruses that made this initial jump to apes. In stark contrast, modern chimpanzee and gorilla CD4 orthologs are more resistant to these viruses. To investigate how this resistance in CD4 was gained, we acquired

Identifiers

PMID38014262
PMCPMC10680607
OpenAlexW4388671307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.