Evidence map›Paper›PMID 38014248›Full record

ArticlebioRxiv : the preprint server for biology2023

Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum.

S M Mulloy, E M Aback, R Gao, S Engel, K Pawaskar, C Win, A Moua, L Hillukka, A M Lee

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

S M MulloyGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.
E M AbackDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
R GaoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
S EngelDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
K PawaskarDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
C WinDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
A MouaDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
L HillukkaDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
A M LeeGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-4551-0082
University of Minnesota · US

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
Dissecting nicotinic receptor contributions to alcohol aversionR01AA026598 · NIAAA · UNIVERSITY OF MINNESOTA · PI LEE, ANNA M. · 2018 to 2022
$1.7M
NIAAA NIH HHS R01 AA026598NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

Ethanol engages cholinergic signaling and elicits endogenous acetylcholine release. Acetylcholine input to the midbrain originates from the mesopontine tegmentum (MPT), which is composed of the laterodorsal tegmentum (LDT) and the pedunculopontine tegmental nucleus (PPN). We investigated the effect of acute and chronic ethanol administration on cholinergic and glutamatergic neuron activation in the PPN and LDT in male and female mice. We show that ethanol selectively activates neurons of the PPN and not the LDT in male mice. Acute 4.0 g/kg and chronic 15 daily injections of 2.0 g/kg

Identifiers

PMID38014248
PMCPMC10680559
OpenAlexW4388648053

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.