Evidence map›Paper›PMID 38014227›Full record

ArticlebioRxiv : the preprint server for biology2024

The unusual structural properties and potential biological relevance of switchback DNA.

Bharath Raj Madhanagopal, Hannah Talbot, Arlin Rodriguez, Jiss Maria Louis, Hana Zeghal, Sweta Vangaveti, Kaalak Reddy, Arun Richard Chandrasekaran

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bharath Raj MadhanagopalThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Hannah TalbotThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Arlin RodriguezThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Jiss Maria LouisThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Hana ZeghalThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Sweta VangavetiThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Kaalak ReddyThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, NY, USA.
Albany State University · US

Funding

Programmable DNA Nanostructures as Biomedical and Structural ScaffoldsR35GM150672 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Arun Richard Chandrasekaran · 2023 to 2026
$1.7M
NIGMS NIH HHS R35 GM150672
6 · The paper itself

Abstract

Synthetic DNA motifs form the basis of nucleic acid nanotechnology, and their biochemical and biophysical properties determine their applications. Here, we present a detailed characterization of switchback DNA, a globally left-handed structure composed of two parallel DNA strands. Compared to a conventional duplex, switchback DNA shows lower thermodynamic stability and requires higher magnesium concentration for assembly but exhibits enhanced biostability against some nucleases. Strand competition and strand displacement experiments show that component sequences have an absolute preference for duplex complements instead of their switchback partners. Further, we hypothesize a potential role for switchback DNA as an alternate structure in sequences containing short tandem repeats. Together with small molecule binding experiments and cell studies, our results open new avenues for switchback DNA in biology and nanotechnology.

Identifiers

PMID38014227
PMCPMC10680705
OpenAlexW4388753946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.