Evidence map›Paper›PMID 38014178›Full record

ArticlebioRxiv : the preprint server for biology2023

Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.

Abhishek K Singh, Balkrishna Chaube, Kathryn M Citrin, Joseph Wayne Fowler, Sungwoon Lee, Jonatas Catarino, James Knight, Sarah Lowery, Sonal Shree, Nabil Boutagy and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Abhishek K SinghDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.ORCID 0000-0002-4474-1367
Balkrishna ChaubeDepartment of Comparative Medicine, Yale Center for Molecular and Systems Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Kathryn M CitrinDepartment of Comparative Medicine, Yale Center for Molecular and Systems Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Joseph Wayne FowlerDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Sungwoon LeeDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Jonatas CatarinoIntegrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
James KnightDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.
Sarah LoweryChemistry Research Building, Yale University, New Haven, CT, USA.
Sonal ShreeMolecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Nabil BoutagyDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Inmaculada Ruz-MaldonadoDepartment of Comparative Medicine, Yale Center for Molecular and Systems Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Kathy HarryDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Marya ShanabroughIntegrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Trenton Thomas RossInternal Medicine Research Unit (IMRU), Pfizer, Cambridge, MA, USA.
Stacy MalakerChemistry Research Building, Yale University, New Haven, CT, USA.
Yajaira SuárezDepartment of Comparative Medicine, Yale Center for Molecular and Systems Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Carlos Fernández-HernandoDepartment of Comparative Medicine, Yale Center for Molecular and Systems Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Kariona GrabinskaDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
William C SessaDepartment of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.ORCID 0000-0001-5759-1938
Yale University · USPfizer (United States) · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
Insights into the Molecular and Cellular Mechanisms governing Endothelial FunctionR35HL139945 · NHLBI · YALE UNIVERSITY · PI SESSA, WILLIAM C · 2018 to 2021
$4.3M
Role of lipid droplets in insulin resistanceR01DK125492 · NIDDK · YALE UNIVERSITY · PI FERNANDEZ HERNANDO, CARLOS · 2020 to 2023
$1.8M
Endothelial lipid droplet turnover and regulation of metabolic functionK01DK124441 · NIDDK · YALE UNIVERSITY · PI BOUTAGY, NABIL · 2020 to 2022
$562k
NHLBI NIH HHS R35 HL139945NIDDK NIH HHS K01 DK124441NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK125492
6 · The paper itself

Abstract

Obesity-linked fatty liver is a significant risk factor for hepatocellular carcinoma (HCC)

Identifiers

PMID38014178
PMCPMC10680637
OpenAlexW4388692049

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.