Evidence map›Paper›PMID 38014173›Full record

ArticlebioRxiv : the preprint server for biology2024

A double-ring of human RAD52 remodels replication forks restricting fork reversal.

Masayoshi Honda, Mortezaali Razzaghi, Paras Gaur, Eva Malacaria, Giorgia Marozzi, Ludovica Di Biagi, Francesca Antonella Aiello, Emeleeta A Paintsil, Andrew J Stanfield, Bailey J Deppe and 5 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Mortezaali RazzaghiORCID 0000-0002-5048-3624
Ludovica Di BiagiORCID 0000-0002-1791-8593
Francesca Antonella AielloORCID 0000-0003-3013-4504
Emeleeta A PaintsilORCID 0000-0003-2110-0652
Andrew J Stanfield
Bailey J Deppe
Nicholas J SchnickerORCID 0000-0002-5189-4943
M Ashley Spies
University of Iowa · USIstituto Superiore di Sanità · ITMedical College of Wisconsin · USQ Therapeutics (United States) · US

Funding

The Role of Human RAD52 Protein in Genome StabilityR01CA232425 · NCI · UNIVERSITY OF IOWA · PI Maria Spies · 2019 to 2026
$3.1M
NCI NIH HHS R01 CA232425
6 · The paper itself

Abstract

Human RAD52 One Sentence Summary: Using cryo-EM, biochemical and single-molecule approaches we show that the structure of stalled DNA replication fork promotes a unique two-ring organization of human RAD52 protein which remodels the fork via DNA strand exchange.

Identifiers

PMID38014173
PMCPMC10680749
OpenAlexW4388680760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.