Evidence map›Paper›PMID 38014142›Full record

ArticlebioRxiv : the preprint server for biology2023

COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells.

Ludovic Pelosi, Laura Morbiato, Arthur Burgardt, Fiorella Tonello, Abigail K Bartlett, Rachel M Guerra, Katayoun Kazemzadeh Ferizhendi, Maria Andrea Desbats, Bérengère Rascalou, Marco Marchi and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 5 countries.

Ludovic PelosiUniversité Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Laura MorbiatoClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Arthur BurgardtGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.
Fiorella TonelloCNR Institute of Neuroscience, I-35121 Padova, Italy.
Abigail K BartlettDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Rachel M GuerraDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Katayoun Kazemzadeh FerizhendiUniversité Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Maria Andrea DesbatsClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Bérengère RascalouUniversité Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
Marco MarchiClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Luis Vázquez-FonsecaClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Caterina AgostoPediatric Pain and Palliative Care Unit, Department of Women and Children's Health, University Hospital of Padova, 35128, Padova, Italy.
Giuseppe ZanottiDepartment of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padua, Italy.
Morgane Roger-MargueritatUniversité Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
María Alcázar-FabraCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Laura García-CorzoCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Ana Sánchez-CuestaCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Plácido NavasCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Gloria Brea-CalvoCentro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide and CIBERER, Sevilla, Spain.
Eva TrevissonClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Volker F WendischGenetics of Prokaryotes, Faculty of Biology and Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.
David J PagliariniDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Leonardo SalviatiClinical Genetics Unit, Department of Women and Children's Health, University of Padova, 35128, Padova, Italy.
Fabien PierrelUniversité Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000 Grenoble, France.
University of Padua · ITCentro Andaluz de Biología del Desarrollo · ESInstitut polytechnique de Grenoble · FRBielefeld University · DEUniversity of Wisconsin–Madison · USNeuroscience Institute · ITWashington University in St. Louis · US

Funding

Systems-to-structure approaches for defining mitochondrial protein functionR35GM131795 · NIGMS · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2019 to 2026
$4.8M
NIGMS NIH HHS R35 GM131795
6 · The paper itself

Abstract

Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and homeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ proteins. Two steps of the eukaryotic pathway, the decarboxylation and hydroxylation of position C1, have remained uncharacterized. Here, we provide evidence that these two reactions occur in a single oxidative decarboxylation step catalyzed by COQ4. We demonstrate that COQ4 complements an

Indexed as

Coenzyme QCoenzyme Q biosynthesisCoenzyme Q deficiencyCOQ4mitochondriaOxidative decarboxylationrespiratory chain

Identifiers

PMID38014142
PMCPMC10680789
OpenAlexW4388645752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.