Evidence map›Paper›PMID 38014136›Full record

ArticlebioRxiv : the preprint server for biology2023

GCN2 mediates access to stored amino acids for somatic maintenance during

Joshua N Johnstone, Christen K Mirth, Travis K Johnson, Ralf B Schittenhelm, Matthew D W Piper

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joshua N JohnstoneSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-8523-9269
Christen K MirthSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0002-9765-4021
Travis K JohnsonSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0001-6846-9313
Ralf B SchittenhelmMonash Proteomics and Metabolomics Platform, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.ORCID 0000-0001-8738-1878
Matthew D W PiperSchool of Biological Sciences, Monash University, Melbourne, Australia.ORCID 0000-0003-3245-7219
Monash University · AUAustralian Regenerative Medicine Institute · AULa Trobe University · AU

Funding

Coordinating Center for the Undiagnosed Diseases NetworkU01HG007530 · NHGRI · HARVARD MEDICAL SCHOOL · PI KOHANE, ISAAC S. · 2014 to 2022
$30.2M
NHGRI NIH HHS U01 HG007530
6 · The paper itself

Abstract

Many mechanistic theories of ageing argue that a progressive failure of somatic maintenance, the use of energy and resources to prevent and repair damage to the cell, underpins ageing. To sustain somatic maintenance an organism must acquire dozens of essential nutrients from the diet, including essential amino acids (EAAs), which are physiologically limiting for many animals. In

Indexed as

amino acid deprivationDrosophilaGCN2longevitysomatic maintenance

Identifiers

PMID38014136
PMCPMC10680771
OpenAlexW4388703911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.