Evidence map›Paper›PMID 38014135›Full record

ArticlebioRxiv : the preprint server for biology2023

Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections.

Marisa D Ruehle, Sam Li, David A Agard, Chad G Pearson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Marisa D RuehleDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sam LiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
David A AgardDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3512-695X
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-1915-6593

Funding

Structure & Mechanism: microtubule nucleation, centrosomes, phage cytoskeletonR35GM118099 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A. · 2016 to 2022
$3.6M
Centriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5M
MIPS (Microtubule Inner Proteins) function in cilia and basal bodiesR01GM127571 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WINEY, MARK · 2018 to 2025
$2.5M
Building Centrioles: Mechanism and StructureF32GM122239 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI RUEHLE, MARISA · 2017 to 2019
$177k
NIGMS NIH HHS F32 GM122239NIGMS NIH HHS R01 GM127571NIGMS NIH HHS R35 GM118099NIGMS NIH HHS R35 GM140813
6 · The paper itself

Abstract

Basal bodies (BBs) are conserved eukaryotic structures that organize motile and primary cilia. The BB is comprised of nine, cylindrically arranged, triplet microtubules (TMTs) that are connected to each other by inter-TMT linkages which maintain BB structure. During ciliary beating, forces transmitted to the BB must be resisted to prevent BB disassembly. Poc1 is a conserved BB protein important for BBs to resist ciliary forces. To understand how Poc1 confers BB stability, we identified the precise position of Poc1 binding in the

Indexed as

basal bodyciliainner junctionmicrotubule

Identifiers

PMID38014135
PMCPMC10680851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.