ArticlebioRxiv : the preprint server for biology2024
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Guoqiang Wang, Ryan Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic and 4 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 2 institutions in 1 country.
Guoqiang WangDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-3694-7103 Ryan GuaspDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Sangeena SalamDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0001-9678-4134 Edward ChuangDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-6380-7317 Andrés MoreraDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Anna J SmartDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0001-9104-6263 David JimenezDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Sahana ShekharDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Emily FriedmanDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Ilija MelentijevicDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-0029-522X Ken C NguyenDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.ORCID 0000-0001-8459-9820 Barth D GrantDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-5943-8336 Monica DriscollDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-8751-7429 Rutgers, The State University of New Jersey · USAlbert Einstein College of Medicine · US
Funding
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MDefining Roles of Genetics and Age in Extrusion of Neurotoxic AggregatesR37AG056510 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2017 to 2026
$5.3MUnderstanding the Exopher: A Novel Mechanism for Extrusion of Neurotoxic ContentsR01AG047101 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI DRISCOLL, MONICA A., GRANT, BARTH DEMIAN · 2013 to 2022
$4.2MMolecular regulation of endosome fission during endocytic recyclingR01GM135326 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Barth Demian Grant · 2020 to 2026
$2.6MNIA NIH HHS R01 AG047101NIA NIH HHS R37 AG056510NIGMS NIH HHS R01 GM135326NIH HHS P40 OD010440NIH HHS R24 OD010943
6 · The paper itselfAbstract
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, such as exophers produced by proteostressed
Identifiers
PMID38014134
PMCPMC10680645
OpenAlexW4388744599
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