Evidence map›Paper›PMID 38014118›Full record

ArticlebioRxiv : the preprint server for biology2023

Intranasal GHK peptide enhances resilience to cognitive decline in aging mice.

Matthew Tucker, Addison Keely, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Warren Ladiges

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matthew TuckerDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Addison KeelyDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Joo Young ParkDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Manuela RosenfeldDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Jackson WezemanDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Ruby MangalindanDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
Dan RatnerDepartment of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle WA.
Warren LadigesDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle WA.
University of Washington · US

Funding

Physical resilience is a predictor of healthy aging in miceR01AG057381 · NIA · UNIVERSITY OF WASHINGTON · PI Warren C LADIGES · 2017 to 2026
$4.6M
NIA NIH HHS R01 AG057381
6 · The paper itself

Abstract

Brain aging and cognitive decline are aspects of growing old. Age-related cognitive impairment entails the early stages of cognitive decline, and is extremely common, affecting millions of older people. Investigation into early cognitive decline as a treatable condition is relevant to a wide range of cognitive impairment conditions, since mild age-related neuropathology increases risk for more severe neuropathology and dementia associated with Alzheimer's Disease. Recent studies suggest that the naturally occurring peptide GHK (glycyl-L-histidyl-L-lysine) in its Cu-bound form, has the potential to treat cognitive decline associated with aging. In order to test this concept, male and female C57BL/6 mice, 20 months of age, were given intranasal GHK-Cu, 15 mg/kg daily, for two months. Results showed that mice treated with intranasal GHK-Cu had an enhanced level of cognitive performance in spatial memory and learning navigation tasks, and expressed decreased neuroinflammatory and axonal damage markers compared to mice treated with intranasal saline. These observations suggest that GHK-Cu can enhance resilience to brain aging, and has translational implications for further testing in both preclinical and clinical studies using an atomizer device for intranasal delivery.

Indexed as

Aging mouse modelBrain agingCognitive declineGHK-CuIntranasal deliveryNeuropathology

Identifiers

PMID38014118
PMCPMC10680828
OpenAlexW4388752804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.