Evidence map›Paper›PMID 38014100›Full record

ArticlebioRxiv : the preprint server for biology2023

The Dmc1 recombinase physically interacts with and promotes the meiotic crossover functions of the Mlh1-Mlh3 endonuclease.

Gianno Pannafino, Jun Jie Chen, Viraj Mithani, Lisette Payero, Michael Gioia, J Brooks Crickard, Eric Alani

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gianno PannafinoDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
Jun Jie ChenDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
Viraj MithaniDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
Lisette PayeroDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
Michael GioiaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
J Brooks CrickardDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.
Eric AlaniDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA 14853.ORCID 0000-0002-5011-9339
Cornell University · US

Funding

Roles for Mismatch Repair Proteins in Maintaining Genome StabilityR35GM134872 · NIGMS · CORNELL UNIVERSITY · PI Eric E. Alani · 2020 to 2026
$2.8M
Molecular Mechanisms of Human Homologous RecombinationR35GM142457 · NIGMS · CORNELL UNIVERSITY · PI John Brooks Crickard · 2021 to 2026
$2.3M
Uncovering the Role of Exo1 in Meiotic RecombinationF31GM145163 · NIGMS · CORNELL UNIVERSITY · PI PAYERO, LISETTE · 2022 to 2024
$98k
NIGMS NIH HHS F31 GM145163NIGMS NIH HHS R35 GM134872NIGMS NIH HHS R35 GM142457
6 · The paper itself

Abstract

The accurate segregation of homologous chromosomes during the Meiosis I reductional division in most sexually reproducing eukaryotes requires crossing over between homologs. In baker's yeast approximately 80 percent of meiotic crossovers result from Mlh1-Mlh3 and Exo1 acting to resolve double-Holliday junction (dHJ) intermediates in a biased manner. Little is known about how Mlh1-Mlh3 is recruited to recombination intermediates and whether it interacts with other meiotic factors prior to its role in crossover resolution. We performed a haploinsufficiency screen in baker's yeast to identify novel genetic interactors with Mlh1-Mlh3 using sensitized

Indexed as

crossing overDmc1Holliday junction resolutionmeiotic recombinationMlh1Mlh3

Identifiers

PMID38014100
PMCPMC10680668
OpenAlexW4388645732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.