Evidence map›Paper›PMID 38014085›Full record

ArticlebioRxiv : the preprint server for biology2023

A nuclear architecture screen in

Ankita Chavan, Randi Isenhart, Son C Nguyen, Noor Kotb, Jailynn Harke, Anna Sintsova, Gulay Ulukaya, Federico Uliana, Caroline Ashiono, Ulrike Kutay and 4 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Ankita ChavanInstitute of Biochemistry, Department of Biology, ETH Zürich, Switzerland.
Randi IsenhartPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Son C NguyenPenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Noor KotbDepartment of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jailynn HarkePenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Anna SintsovaInstitute of Microbiology, Department of Biology, ETH Zürich, Switzerland.
Gulay UlukayaBioinformatics for Next Generation Sequencing (BiNGS) core, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Federico UlianaInstitute of Biochemistry, Department of Biology, ETH Zürich, Switzerland.
Caroline AshionoInstitute of Biochemistry, Department of Biology, ETH Zürich, Switzerland.
Ulrike KutayInstitute of Biochemistry, Department of Biology, ETH Zürich, Switzerland.
Gianluca PegoraroHigh Throughput Imaging Facility (HiTIF), National Cancer Institute, NIH, Bethesda, MD 20892 USA.
Prashanth RanganDepartment of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eric F JoycePenn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Madhav JagannathanInstitute of Biochemistry, Department of Biology, ETH Zürich, Switzerland.
ETH Zurich · CHUniversity of Pennsylvania · USNew York Stem Cell Foundation · USHigh Throughput Biology (United States) · USIcahn School of Medicine at Mount Sinai · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Regulation of chromatin folding in space and timeR35GM128903 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Eric F. Joyce · 2018 to 2026
$4.2M
Regulation of stem cell differentiation during Drosophila oogenesisR01GM111779 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI RANGAN, PRASHANTH · 2014 to 2022
$2.7M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Role of RNA degradation in germline stem cell to oocyte transitionR01GM135628 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI RANGAN, PRASHANTH · 2020 to 2023
$1.3M
Evaluating novel architectural proteins as therapeutic targets for cohesin dysfunctionR21HD107261 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI JOYCE, ERIC F. · 2022 to 2023
$447k
Cellular rejuvenation during oogenesisR56AG082906 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAPELSON, MAYA, RANGAN, PRASHANTH · 2023 to 2023
$387k
NCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA196521NIA NIH HHS R56 AG082906NICHD NIH HHS R21 HD107261NIGMS NIH HHS R01 GM111779NIGMS NIH HHS R01 GM135628NIGMS NIH HHS R35 GM128903NIH HHS S10 OD026880
6 · The paper itself

Abstract

The association of genomic loci to the nuclear periphery is proposed to facilitate cell-type specific gene repression and influence cell fate decisions. However, the interplay between gene position and expression remains incompletely understood, in part because the proteins that position genomic loci at the nuclear periphery remain unidentified. Here, we used an Oligopaint-based HiDRO screen targeting ~1000 genes to discover novel regulators of nuclear architecture in

Indexed as

Genome organizationGermline stem cellHeterochromatinNuclear architectureNuclear periphery

Identifiers

PMID38014085
PMCPMC10680830
OpenAlexW4388798506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.