In one paragraphArticle in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors.
Devasahayam Arokia Balaya RexCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India.ORCID 0000-0002-9556-3150 Dina SchusterDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich 8093, Switzerland; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich 8093, Switzerland; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, Villigen 5232, Switzerland.ORCID 0000-0001-6611-8237 Benjamin A NeelyChemical Sciences Division, National Institute of Standards and Technology, NIST Charleston · Funded by NIST.ORCID 0000-0001-6120-7695 Germán L RosanoMass Spectrometry Unit, Institute of Molecular and Cellular Biology of Rosario, Rosario, Argentina · Funded by Grant PICT 2019-02971 (Agencia I+D+i).ORCID 0000-0002-8313-6813 Norbert VolkmarDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich 8093, Switzerland.ORCID 0000-0003-0766-5606 Amanda MomenzadehDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-8614-0690 Trenton M Peters-ClarkeDepartment of Pharmaceutical Chemistry, University of California-San Francisco.ORCID 0000-0002-9153-2525 Simion KreimerSmidt Heart Institute, Cedars Sinai Medical Center; Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center.ORCID 0000-0001-6627-3771 Emma H DoudCenter for Proteome Analysis, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-0049-0073 Oliver M CrookOxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, United Kingdom.ORCID 0000-0001-5669-8506 Amit Kumar YadavTranslational Health Science and Technology Institute · Funded by Grant BT/PR16456/BID/7/624/2016 (Department of Biotechnology, India); Grant Translational Research Program (TRP) at THSTI funded by DBT.ORCID 0000-0002-9445-8156 Muralidharan VanuopadathSchool of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam-690 525, Kerala, India · Funded by Department of Health Research, Indian Council of Medical Research, Government of India (File No.R.12014/31/2022-HR).ORCID 0000-0002-9364-917X Martín L MaytaSchool of Medicine and Health Sciences, Center for Health Sciences Research, Universidad Adventista del Plata, Libertador San Martín 3103, Argentina; Molecular Biology Department, School of Pharmacy and Biochemistry, Universidad Nacional de Rosario, Rosario 2000, Argentina.ORCID 0000-0002-7986-4551 Anna G DuboffDepartment of Chemistry, University of Washington · Funded by Summer Research Acceleration Fellowship, Department of Chemistry, University of Washington.ORCID 0009-0002-7316-3831 Nicholas M RileyDepartment of Chemistry, University of Washington · Funded by National Institutes of Health Grant R00 GM147304.ORCID 0000-0002-1536-2966 Robert L MoritzInstitute for Systems biology, Seattle, WA, USA, 98109 · Funded by National Institutes of Health Grants R01GM087221, R24GM127667, U19AG023122, S10OD026936; National Science Foundation Award 1920268.ORCID 0000-0002-3216-9447 Jesse G MeyerDepartment of Computational Biomedicine, Cedars Sinai Medical Center · Funded by National Institutes of Health Grant R21 AG074234; National Institutes of Health Grant R35 GM142502.ORCID 0000-0003-2753-3926 Funding
Democratizing Multi-Omics to Expedite Discovery of Hidden Metabolic PathwaysR35GM142502 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI MEYER, JESSE · 2021 to 2025
$2.2MDrug Discovery for Alzheimer’s Disease Enabled by Multi-Omics and Artificial IntelligenceR21AG074234 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI MEYER, JESSE · 2021 to 2022
$443kNIA NIH HHS R21 AG074234NIGMS NIH HHS R35 GM142502
6 · The paper itselfAbstract
Proteomics is the large scale study of protein structure and function from biological systems through protein identification and quantification. "Shotgun proteomics" or "bottom-up proteomics" is the prevailing strategy, in which proteins are hydrolyzed into peptides that are analyzed by mass spectrometry. Proteomics studies can be applied to diverse studies ranging from simple protein identification to studies of proteoforms, protein-protein interactions, protein structural alterations, absolute and relative protein quantification, post-translational modifications, and protein stability. To enable this range of different experiments, there are diverse strategies for proteome analysis. The nuances of how proteomic workflows differ may be challenging to understand for new practitioners. Here, we provide a comprehensive overview of different proteomics methods to aid the novice and experienced researcher. We cover from biochemistry basics and protein extraction to biological interpretation and orthogonal validation. We expect this work to serve as a basic resource for new practitioners in the field of shotgun or bottom-up proteomics.
Identifiers
PMID38013887
PMCPMC10680866
What OpenQuestion holds
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LicenceCC BY-NC-ND
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