Evidence map›Paper›PMID 38013773›Full record

ArticleNutrition and healthy aging2023

Measures of MRI Brain Biomarkers in Middle Age According to Average Modified Mediterranean Diet Scores Throughout Young and Middle Adulthood.

Zeinah Al-Darsani, David R Jacobs, R Nick Bryan, Lenore J Launer, Lyn M Steffen, Kristine Yaffe, James M Shikany, Andrew O Odegaard

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and healthy aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Zeinah Al-DarsaniDepartment of Epidemiology and Biostatistics, University of California, Irvine, Irvine, CA, USA.
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
R Nick BryanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.
Lyn M SteffenDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Kristine YaffeDepartment of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, USA.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Andrew O OdegaardDepartment of Epidemiology and Biostatistics, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USUniversity of Minnesota · USNational Institute on Aging · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US

Funding

Population Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8M
Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia PreventionR01AG063887 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI YAFFE, KRISTINE · 2019 to 2022
$3.0M
NIA NIH HHS R01 AG063887NIA NIH HHS R35 AG071916
6 · The paper itself

Abstract

backgroundThe Mediterranean diet (MedDiet) has been linked with better cognitive function and brain integrity.

objectiveTo examine the association of modified Mediterranean diet (mMedDiet) scores from early through middle adulthood in relation to volumetric and microstructural midlife MRI brain measures. Assess the association of mMedDiet and brain measures with four cognitive domains. If variables are correlated, determine if brain measures mediate the relationship between mMedDiet and cognition.

methods618 participants (mean age 25.4±3.5 at year 0) of the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cumulative average mMedDiet scores were calculated by averaging scores from years 0, 7, and 20. MRI scans were obtained at years 25 and 30. General linear models were used to examine the association between mMedDiet and brain measures.

resultsHigher cumulative average mMedDiet scores were associated with better microstructural white matter (WM) integrity measured by fractional anisotropy (FA) at years 25 and 30 (all p

conclusionsmMedDiet scores may be associated with microstructural WM integrity at midlife.

Indexed as

biomarkerscognitionlife courseMediterranean dietmidlifeMRI

Identifiers

PMID38013773
PMCPMC10475985
OpenAlexW4385350724

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.