Evidence map›Paper›PMID 38013469›Full record

ArticleActa biochimica et biophysica Sinica2024

Dexmedetomidine ameliorates high glucose-induced epithelial-mesenchymal transformation in HK-2 cells through the Cdk5/Drp1/ROS pathway.

Fei Wang, Weilong Xu, Xiaoge Liu, Jun Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. S100A1 Promotes MDM2-Mediated KLF15 Ubiquitination to Regulate ID1-Driven Tubular Injury in Diabetic Kidney Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
  3. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fei WangDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Weilong XuDepartment of Anesthesiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Xiaoge LiuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Jun ZhangDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal transformation (EMT) plays an important role in the progression of diabetic nephropathy. Dexmedetomidine (DEX) has shown renoprotective effects against ischemic reperfusion injury; however, whether and how DEX prevents high glucose-induced EMT in renal tubular epithelial cells is incompletely known. Here, we conduct

Indexed as

DexmedetomidineEpithelial-Mesenchymal TransitionSignal TransductionCadherinsCyclin-Dependent Kinase 5DynaminsEpithelial CellsGlucoseHumansReactive Oxygen SpeciesRoscovitineCadherinsCDK5 protein, humanCyclin-Dependent Kinase 5DexmedetomidineDNM1L protein, humanDynaminsGlucoseReactive Oxygen SpeciesRoscovitinecyclin-dependent kinase 5dexmedetomidinedynamin-related protein 1epithelial-mesenchymal transformationhigh glucose

Identifiers

PMID38013469
PMCPMC10875345
OpenAlexW4386052574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.