Evidence map›Paper›PMID 38013439›Full record

ReviewCurrent medicinal chemistry2025

Recent Progress on Natural α-Glucosidase Inhibitors Derived from the Plants and Microorganisms.

Changxuan Deng, Nan Zhang, Hanlin Lin, Wangting Lu, Fei Ding, Yangguang Gao, Yongmin Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Phytochemical Profiling andFoods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changxuan DengKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.
Nan ZhangKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.
Hanlin LinKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.
Wangting LuKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.
Fei DingKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.
Yangguang GaoKey Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Institute for Interdisciplinary Research, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, Hubei, China.ORCID 0000-0001-5691-3130
Yongmin ZhangInstitut Parisien de Chimie Moléculaire, UMR 8232 CNRS, Sorbonne Université, Paris 75005, France.

Funding

Excellent Discipline Cultivation Project of Jianghan University 2023XKZ039NSF of China 21602082Research Fund of Jianghan University 2023KJZX06
6 · The paper itself

Abstract

α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase inhibitors are mostly discovered from plants and microorganisms, the recent advance in natural α- glucosidase inhibitors over the past five years has been reviewed in this article, and 139 distinct α-glucosidase inhibitors from the plants and microorganisms were classified into ten groups based on their chemical structures, including flavonoids (34), xanthones (6), alkaloids (8), benzopyrones / benzofuranones (8), terpenes (25), saponins (6), phenols / alcohols (25), esters (20), chalcone (5) and other compounds (2). In this review, we mainly focused on the novel chemical structures and the various biological activities of theses natural AGIs. Some of the selected natural compounds exhibit powerful α-glucosidase inhibitory activity and anti-tumor activity, may hold promise to become the candidate drugs for treating type II diabetes and cancer in future.

Indexed as

alpha-GlucosidasesBacteriaBiological ProductsGlycoside Hydrolase InhibitorsPlantsAntineoplastic AgentsHumansHypoglycemic AgentsMolecular Structurealpha-GlucosidasesAntineoplastic AgentsBiological ProductsGlycoside Hydrolase InhibitorsHypoglycemic Agentsanticancerbiological activitydiabetes mellitusflavonoidhypoglycemic.α-glucosidase inhibitors

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.