Evidence map›Paper›PMID 38013426›Full record

SynthesisHuman vaccines & immunotherapeutics2023

Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years.

Xiao-Li Fu, Yan Ma, Zheng Li, Yang-Yang Qi, Si-Jie Wang, Li-Jun Fu, Song-Mei Wang, Lorenz von Seidlein, Xuan-Yi Wang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Xiao-Li FuKey Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yan MaDepartment of Infectious Disease Prevention and Control, Shaoxing Center for Disease Control and Prevention, Shaoxing, China.
Zheng LiShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Yang-Yang QiShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Si-Jie WangKey Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Li-Jun FuDepartment of Infectious Disease Prevention and Control, Shaoxing Center for Disease Control and Prevention, Shaoxing, China.
Song-Mei WangLaboratory of Molecular Biology, Training Center of Medical Experiments, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Lorenz von SeidleinMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Xuan-Yi WangKey Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID 0000-0001-6398-9184
Fudan University · CNTaiwan Centers for Disease Control · TWMahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute gastroenteritis (AGE) caused by rotavirus (RV) remains a public health issue in China. To accelerate the mass rotavirus vaccination, it is important to inform the policy maker, and the public of the economic burden caused by rotavirus infection. A meta-analysis was conducted applying standardized algorithms. Articles published before January 1, 2023, in English and Chinese were searched through PubMed, CNKI, and WanFang Data. Studies with cost analysis of RV AGE were included. A random-effects model was applied to synthesize the total cost of RV AGE from the societal perspective. A prospective survey aimed to measure the cost of RV AGE was conducted in 2021 and 2022 in Shaoxing city, Zhejiang province, that can represent the developed region. The cost data was applied as deviation indicator, in comparison with the pooled estimate generated from meta-analysis. Totally 286 articles were identified, and eventually 12 studies were included. The pooled total social cost of RV AGE was US$282.1 (95%CI: US$213.4-350.7). The pooled private cost of RV AGE was US$206.4 (95%CI: US$155.2-257.5). RV AGE hospitalized and RV AGE incurred in developed regions caused remarkable higher burden (US$631.2 [95%CI: US$512.6-749.8], and US$333.6 [95%CI: US$234.1-433.2] respectively), compared to RV AGE treated at outpatient, and incurred in less developed regions. Our study demonstrates that RV AGE causes a significant economic burden in China. Given the promising effectiveness and highly cost-effective, introduction of rotavirus vaccines in national immunization programs could substantially reduce the economic burden in China.

Indexed as

GastroenteritisRotavirus InfectionsRotavirus VaccinesChild, PreschoolCost-Benefit AnalysisEast Asian PeopleHumansInfantMass VaccinationProspective StudiesRotavirusRotavirus Vaccinesacute gastroenteritisChinaeconomic burdenRotavirus

Identifiers

PMID38013426
PMCPMC10760361
OpenAlexW4389097757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.