Evidence map›Paper›PMID 38013241›Full record

ArticleFEBS open bio2024

Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development.

Cristina González, Lidia Martínez-Sánchez, Paula Clemente, Janne Markus Toivonen, Juan José Arredondo, Miguel Ángel Fernández-Moreno, José Alberto Carrodeguas

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cristina GonzálezDepartamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", The Autonomous University of Madrid-Consejo Superior de Investigaciones Científicas, Spain.
Lidia Martínez-SánchezDepartamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", The Autonomous University of Madrid-Consejo Superior de Investigaciones Científicas, Spain.
Paula ClementeDepartamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", The Autonomous University of Madrid-Consejo Superior de Investigaciones Científicas, Spain.
Janne Markus ToivonenLAGENBIO, Departamento de Anatomía, Embriología y Genética Animal, Facultad de Veterinaria, Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, Spain.
Juan José ArredondoDepartamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", The Autonomous University of Madrid-Consejo Superior de Investigaciones Científicas, Spain.
Miguel Ángel Fernández-MorenoCentro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Facultad de Medicina, UAM, Madrid, Spain.
José Alberto CarrodeguasIIS Aragón, Zaragoza, Spain.ORCID 0000-0003-0062-1029
Consejo Superior de Investigaciones Científicas · ESUniversidad de Zaragoza · ES

Funding

Ministerio de Ciencia e Innovación BFU2009-11800Ministerio de Ciencia e Innovación PID2019-110320RB-I0Ramón y Cajal Program RYC-2011-08363Universidad de Zaragoza UZ2010-BIO-03
6 · The paper itself

Abstract

Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins.

Indexed as

DrosophilaMitochondrial ProteinsAnimalsApoptosisDrosophila ProteinsHumansMembrane ProteinsMitochondriaMitochondrial Membrane Transport ProteinsDrosophila ProteinsMembrane ProteinsMitochondrial Membrane Transport ProteinsMitochondrial ProteinsMTCH1 protein, humanMtch protein, DrosophilaapoptosisdevelopmentDrosophilamitochondriamitochondrial carrier homolog (MTCH)

Identifiers

PMID38013241
PMCPMC10839352
OpenAlexW4389097558

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.