Evidence map›Paper›PMID 38012748›Full record

ArticleParasites & vectors2023

Comparison of the initial and residual speed of Ixodes scapularis kill on dogs treated with a single dose of Bravecto

Kathryn E Reif, Naemi P Bickmeier, Brian H Herrin, Michael W Dryden, Dorothy M Normile, Jeba R J Jesudoss Chelladurai, Kamilyah R Miller, Macy R Flowers, Qing Kang

Open access · goldAbstract readRandomized Controlled Trial, Veterinary
In one paragraph

Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kathryn E ReifDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA. kreif@vet.k-state.edu.
Naemi P BickmeierDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Brian H HerrinDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Michael W DrydenDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Dorothy M NormileMerck Animal Health, 2 Giralda Farms, Madison, NJ, 07940, USA.
Jeba R J Jesudoss ChelladuraiDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Kamilyah R MillerDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Macy R FlowersDepartment of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, 66506, USA.
Qing KangDepartment of Statistics, Kansas State University, Manhattan, KS, 66506, USA.
Kansas State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCompliant ectoparasiticide product use is a comprehensive way to control ticks and reduce the risk of tick-borne pathogen transmission to dogs. Because the systemically acting isoxazoline ectoparasiticides require tick attachment for drug delivery, fast speed of kill is essential to minimize tick-borne pathogen transmission risk.

methodsDogs of satisfactory tick-carrying capacity were randomly allocated to treatment groups and administered, per label instructions, Bravecto

resultsThe untreated control group maintained adequate tick infestations throughout the study. Using geometric means, an existing I. scapularis infestation was controlled by 99.7% and 93.0% 12 h post-treatment and by 100% and 99.5% 24 h post-treatment, for Bravecto

conclusionsIxodes scapularis infestations are controlled more quickly 21 and 28 days post-treatment for dogs administered a single dose of Bravecto

Indexed as

AcaricidesDog DiseasesIxodesTick InfestationsAdministration, OralAnimalsAzetidinesDogsFemaleIsoxazolesMacrolidesMalePyrantelSpiro CompoundsTime FactorsTreatment OutcomeA1443 compoundAcaricidesAzetidinesIsoxazolesMacrolidesmoxidectinPyrantelsarolanerSpiro CompoundsAcaricideBlacklegged tickCanineDeer tickEctoparasiticideIsoxazolinePreventionSpeed of killTickTick control

Identifiers

PMID38012748
PMCPMC10683217
OpenAlexW4389057577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.