ArticleAlzheimer's research & therapy2023
Exploring shared neural substrates underlying cognition and gait variability in adults without dementia.
Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Effects of HD-tDCS targeting prefrontal cortex, cerebellum, and motor cortex on dual-task gait in older adults.Scientific reports · 2025Trial
- Cognitive Function Mediates the Association Between Type 2 Diabetes and Physical Performance Decline in Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- When Walking Outlasts Cognition: Rethinking the Late-Stage of Lewy Body Dementia.Neuro-degenerative diseases · 2026Review
- Gait variability development in autistic individuals across childhood and adulthood.Research square · 2026Article
- Refining Western Dementia-Risk Paradigms: Evidence From a Decade of the Korean Longitudinal Study on Cognitive Aging and Dementia.Journal of Korean medical science · 2025Review
- Structural Brain Abnormalities and Neuropsychiatric Symptoms in Post-COVID Condition.NeuroImmune pharmacology and therapeutics · 2025Article
- Hand Motion Control Ability Between Young and Older Adults: Comparative Study.JMIR formative research · 2025Article
- Alzheimer's disease digital biomarkers multidimensional landscape and AI model scoping review.NPJ digital medicine · 2025Article
- Verbal fluency is associated with Gait impairment in Progressive Supranuclear Palsy.Clinical parkinsonism & related disorders · 2025Article
- Neural control of anticipatory braking and lateral balance predicts fall risk in older adults: BMI-dependent mechanisms.Frontiers in aging neuroscience · 2025Article
- Biological and Physical Performance Markers for Early Detection of Cognitive Impairment in Older Adults.Journal of clinical medicine · 2024Review
- The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial.Journal of Alzheimer's disease reports · 2024Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundHigh gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia. The objective of this study was to identify cortical or subcortical structures of the brain shared by gait variability measured using a body-worn tri-axial accelerometer (TAA) and cognitive function.
methodsThis study is a part of a larger population-based cohort study on cognitive aging and dementia. The study included 207 participants without dementia, with a mean age of 72.6, and 45.4% of them are females. We conducted standardized diagnostic interview including a detailed medical history, physical and neurological examinations, and laboratory tests for cognitive impairment. We obtained gait variability during walking using a body-worn TAA along and measured cortical thickness and subcortical volume from brain magnetic resonance (MR) images. We cross-sectionally investigated the cortical and subcortical neural structures associated with gait variability and the shared neural substrates of gait variability and cognitive function.
resultsHigher gait variability was associated with the lower cognitive function and thinner cortical gray matter but not smaller subcortical structures. Among the clusters exhibiting correlations with gait variability, one that included the inferior temporal, entorhinal, parahippocampal, fusiform, and lingual regions in the left hemisphere was also associated with global cognitive and verbal memory function. Mediation analysis results revealed that the cluster's cortical thickness played a mediating role in the association between gait variability and cognitive function.
conclusionGait variability and cognitive function may share neural substrates, specifically in regions related to memory and visuospatial navigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.