Evidence map›Paper›PMID 38012554›Full record

SynthesisBMC infectious diseases2023

Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis.

Jingyang Chen, Sanaz Yasrebinia, Arshin Ghaedi, Monireh Khanzadeh, Stephan Quintin, Abeer Dagra, Rodeania Peart, Brandon Lucke-Wold, Shokoufeh Khanzadeh

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Jingyang ChenThe First Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China.
Sanaz YasrebiniaTabriz University of Medical Sciences, Tabriz, Iran.
Arshin GhaediStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Monireh KhanzadehGeriatric & Gerontology Department, Medical School, Tehran University of Medical and Health Sciences, Tehran, Iran.
Stephan QuintinDepartment of Neurosurgery, University of Florida, Gainesville, FL, 32610, USA.
Abeer DagraDepartment of Neurosurgery, University of Florida, Gainesville, FL, 32610, USA.
Rodeania PeartDepartment of Neurosurgery, University of Florida, Gainesville, FL, 32610, USA.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, FL, 32610, USA.
Shokoufeh KhanzadehTabriz University of Medical Sciences, Tabriz, Iran. Khshokufe7@gmail.com.
University of Florida · USTabriz University of Medical Sciences · IRFujian Medical University · CNShiraz University of Medical Sciences · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, measures innate-adaptive immune system balance. In this systematic review and meta-analysis, we aim to analyze the current literature to evaluate the diagnostic role of NLR in neonatal sepsis.

methodsPubMed, Web of Science, and Scopus were used to conduct a systematic search for relevant publications published before May 14, 2022.

resultsThirty studies, including 2328 neonates with sepsis and 1800 neonates in the control group, were included in our meta-analysis. The results indicated that NLR is higher in neonates with sepsis compared to healthy controls (SMD = 1.81, 95% CI = 1.14-2.48, P-value < 0.001) in either prospective (SMD = 2.38, 95% CI = 1.40-3.35, P-value < 0.001) or retrospective studies (SMD = 0.87, 95% CI = 0.63-1.12, P-value < 0.001) with a pooled sensitivity of 79% (95% CI = 62-90%), and a pooled specificity of 91% (95% CI = 73-97%). Also, we found that NLR is higher in neonates with sepsis compared to those who were suspected of sepsis but eventually had negative blood cultures (SMD =1.99, 95% CI = 0.76-3.22, P-value = 0.002) with a pooled sensitivity of 0.79% (95% CI = 0.69-0.86%), and a pooled specificity of 73% (95% CI = 54-85%). In addition, neonates with sepsis had elevated levels of NLR compared to other ICU admitted neonates (SMD = 0.73, 95% CI = 0.63-0.84, P < 0.001). The pooled sensitivity was 0.65 (95% CI, 0.55-0.80), and the pooled specificity was 0.80 (95% CI, 0.68-0.88).

conclusionOur findings support NLR as a promising biomarker that can be readily integrated into clinical settings to aid in diagnosing neonatal sepsis. As evidenced by our results, restoring balance to the innate and adaptive immune system may serve as attractive therapeutic targets. Theoretically, a reduction in NLR values could be used to measure therapeutic efficacy, reflecting the restoration of balance within these systems.

Indexed as

Neonatal SepsisSepsisBiomarkersHumansInfant, NewbornLymphocytesNeutrophilsProspective StudiesRetrospective StudiesBiomarkersMeta-analysisNeonatal sepsisNeutrophil to lymphocyte ratioSystematic review

Identifiers

PMID38012554
PMCPMC10683320
OpenAlexW4389068811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.