ArticleNature immunology2024
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells.
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions.Science China. Life sciences · 2026Pooled it
- A T-cell exhaustion-related signature for predicting response to immunotherapy among patients with lung adenocarcinoma.Translational lung cancer research · 2026Article
- FOXP1 Knockdown Reprograms Th9 CAR-T Cells to Overcome Antigen Escape.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Epigenetic insights and innovations for overcoming barriers in CAR-T cell therapy for cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Generation of CCR4/CD7 Bispecific CAR-T Cells Resistant to Fratricide and Exhaustion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- KLF4 overexpression in CAR T cells enhances antitumor potency by preventing exhaustion.Journal for immunotherapy of cancer · 2026Article
- Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.Immunity · 2026Article
- Upregulation of TCF1 and BCL11B in CD8+ effector T cells predicts favorable response to ibrutinib in patients with chronic lymphocytic leukemia.Communications biology · 2026Article
- Article
- ZFP148 is a transcriptional repressor of cytolytic effector CD8Nature immunology · 2026Article
- Rational redesign of antigen binding domain improves in vivo efficacy of the CD22-CAR.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CAR-T cell exhaustion in B cell lymphoma: Current status, mechanisms, and potential solutions.Molecular therapy. Oncology · 2026Review
- Transient loss of KLF2 expression is essential for CD8 effector T cell expansion.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Long noncoding RNA FOXP1-DT modulates regulatory T cells in Graves' disease.Scientific reports · 2026Article
- BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.Nature immunology · 2026Article
- The CD8 immgenT framework as a universal reference of mouse CD8αβ T cell differentiation states.bioRxiv : the preprint server for biology · 2026Article
- Cannabidiol exerts antiinflammatory effects but maintains T effector memory cell differentiation in humans.JCI insight · 2026Article
- Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells.Cancer immunology research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Ziang Zhu *Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Guohua Lou *Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Xiao-Lu Teng *Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Haixia WangDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ying LuoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wangke ShiDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kiddist YihunieDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0863-4863
Shumeng HaoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kole DeGolierDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-4144-7277
Chengheng LiaoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Huocong HuangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qing ZhangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-6595-8995
Terry FryDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tao WangQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-4355-149X
Chen YaoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA. chen.yao@utsouthwestern.edu.ORCID http://orcid.org/0000-0001-6852-5661
Tuoqi WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA. tuoqi.wu@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-4003-1034
The University of Texas Southwestern Medical Center · USUniversity of Colorado Anschutz Medical Campus · USSouthwestern Medical Center · US
Funding
Program stem-like CD8 T cells to enhance antiviral immunity against chronic viral infectionR01AI158294 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Tuoqi Wu · 2022 to 2026
$2.9MHarnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV ReservoirsDP2AI154450 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI YAO, CHEN · 2021 to 2025
$2.5MRejuvenating aged T cell immunity by targeting stem cell-like CD8 T cellsR00AG056524 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2019 to 2021
$733kUnderstand the molecular mechanism of age-associated decline in antiviral CD8 T cell immunityR21AG083398 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2023 to 2024
$451kNIAID NIH HHS DP2 AI154450NIAID NIH HHS R01 AI158294NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524NIA NIH HHS R21 AG083398
Abstract
In cancer and infections, self-renewing stem-like CD8
Indexed as
CD8-Positive T-LymphocytesTranscription FactorsCell DifferentiationChromatinT-Lymphocyte SubsetsChromatinTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.