ArticleNature communications2023
Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects.Synthetic and systems biotechnology · 2026Review
- Metabolic engineering ofSynthetic and systems biotechnology · 2026Article
- Formate-driven efficient pyruvate biosynthesis inSynthetic and systems biotechnology · 2026Article
- FormatotrophicSynthetic and systems biotechnology · 2026Article
- Mitigating protocatechuic acid toxicity in Vibrio natriegens enables poly-3-hydroxybutyrate production from an aromatic carbon source.Applied microbiology and biotechnology · 2026Article
- Halophilic Anaerobic Cultures Enriched with COMicrobial ecology · 2026Article
- An Efficient COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A blueprint for designing the next-generation of synthetic CNature communications · 2025Review
- Adaptively evolvedApplied and environmental microbiology · 2025Article
- Construction of a synthetic biology toolkit for the genetic manipulation in the cellulose-producing strainSynthetic and systems biotechnology · 2025Article
- A comprehensive screening on the effect of Bacillus cereus and Vibrio natriegens bacterial consortia in cement mortar.Scientific reports · 2025Article
- Advancing yeast metabolism for a sustainable single carbon bioeconomy.FEMS yeast research · 2025Review
- Fitness and adaptive evolution of a Rhodococcus sp. harboring dioxin-catabolic plasmids.World journal of microbiology & biotechnology · 2025Article
- Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source.NPJ systems biology and applications · 2025Article
- Seven critical challenges in synthetic one-carbon assimilation and their potential solutions.FEMS microbiology reviews · 2025Review
- Vibrio natriegens: Application of a Fast-Growing Halophilic Bacterium.Advances in biochemical engineering/biotechnology · 2025Review
- Evolutionary engineering ofScience advances · 2024Article
- The Description of Pseudoalteromonas apostichopi sp. nov., Vibrio apostichopi sp. nov., and Marinobacter apostichopi sp. nov. from the Fertilized Eggs and Larvae of Apostichopus japonicus.Current microbiology · 2024Article
- Metabolic engineering of an industrial bacteriumSynthetic and systems biotechnology · 2024Article
- Efficient natural plasmid transformation ofPNAS nexus · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formic acid (FA) has emerged as a promising one-carbon feedstock for biorefinery. However, developing efficient microbial hosts for economically competitive FA utilization remains a grand challenge. Here, we discover that the bacterium Vibrio natriegens has exceptional FA tolerance and metabolic capacity natively. This bacterium is remodeled by rewiring the serine cycle and the TCA cycle, resulting in a non-native closed loop (S-TCA) which as a powerful metabolic sink, in combination with laboratory evolution, enables rapid emergence of synthetic strains with significantly improved FA-utilizing ability. Further introduction of a foreign indigoidine-forming pathway into the synthetic V. natriegens strain leads to the production of 29.0 g · L
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