Evidence map›Paper›PMID 38012187›Full record

ArticleNature communications2023

CAR

Raymond Hall Yip Louie, Curtis Cai, Jerome Samir, Mandeep Singh, Ira W Deveson, James M Ferguson, Timothy G Amos, Helen Marie McGuire, Kavitha Gowrishankar, Thiruni Adikari and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Mapping clinical CAR-T cells: insights from scRNA-seq.Trends in molecular medicine · 2026
    Review
  5. Naïve CD4Nature communications · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Raymond Hall Yip Louie *School of Computer Science and Engineering, UNSW Sydney, Sydney, NSW, Australia.
Curtis Cai *Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-3490-4361
Jerome Samir *Kirby Institute for Infection and Immunity, UNSW Sydney, Sydney, NSW, Australia.
Mandeep SinghGarvan Institute for Medical Research, Sydney, NSW, Australia.ORCID 0000-0002-6998-3805
Ira W DevesonGarvan Institute for Medical Research, Sydney, NSW, Australia.ORCID 0000-0003-3861-0472
James M FergusonGarvan Institute for Medical Research, Sydney, NSW, Australia.ORCID 0000-0002-6192-6937
Timothy G AmosGarvan Institute for Medical Research, Sydney, NSW, Australia.ORCID 0000-0002-5829-6655
Helen Marie McGuireRamaciotti Facility for Human Systems Biology, The University of Sydney, Sydney, NSW, Australia.
Kavitha GowrishankarBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
Thiruni AdikariKirby Institute for Infection and Immunity, UNSW Sydney, Sydney, NSW, Australia.
Robert BalderasBecton Dickinson, San Jose, CA, USA.ORCID 0000-0002-8734-8629
Martina BonomiKirby Institute for Infection and Immunity, UNSW Sydney, Sydney, NSW, Australia.
Marco RuellaDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4301-5811
David BishopBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.ORCID 0000-0001-6415-1455
David GottliebBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
Emily BlythBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.ORCID 0000-0002-7849-7139
Kenneth MicklethwaiteBlood Transplant and Cell Therapies Program, Department of Haematology, Westmead Hospital, Sydney, NSW, Australia.
Fabio LucianiKirby Institute for Infection and Immunity, UNSW Sydney, Sydney, NSW, Australia. luciani@unsw.edu.au.ORCID 0000-0003-0666-6324
Garvan Institute of Medical Research · AUThe University of Sydney · AUUNSW Sydney · AUBecton Dickinson (United States) · USUniversity of Pennsylvania · USWestmead Hospital · AU

Funding

Project 3: Combinatorial and gene-editing approaches to enhance the efficacy of CAR T cell therapy of multiple myeloma.P01CA214278 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Joseph Anthony Fraietta · 2017 to 2026
$26.8M
MODULATION OF CD5 SIGNALING TO ENHANCE ADOPTIVE T-CELL THERAPIES FOR CANCERR37CA262362 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Marco Ruella · 2022 to 2026
$2.6M
NCI NIH HHS P01 CA214278NCI NIH HHS R37 CA262362
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies, but factors influencing the persistence of functional CAR

Indexed as

Lymphoma, Large B-Cell, DiffuseReceptors, Antigen, T-CellB-LymphocytesHumansImmunotherapy, AdoptiveT-LymphocytesReceptors, Antigen, T-Cell

Identifiers

PMID38012187
PMCPMC10682404
OpenAlexW4389048928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.